Results 111 to 120 of about 12,777,871 (250)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The impact of increased renewable energy penetration and reduced inertia on the frequency nadir in a multi-area interconnected network based on the peninsula Malaysia national grid

Global Energy Interconnection
The increased adoption of renewable energy sources (RES) has left the power system grid with ever more decreasing inertia. The inertia plays a crucial part in mitigating frequency changes in the power system.
Ousama M.T. Ajami, Maadh S.J. Alkhusaibi, Rodney H.G. Tan, Farah Adilah Jamaludin, Mithulananthan Nadarajah   +4 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Optimization of Frequency Stability in Hydraulic Load Frequency Control Systems Using Controllers with Filters

Andalas Journal of Electrical and Electronic Engineering Technology
This study meticulously investigates the design and analysis of a Load Frequency Control (LFC) system tailored explicitly for hydraulic power systems by employing diverse configurations of PID controllers, namely Proportional (P), Proportional-Integral ...
Heru Dibyo Laksono, Dhea Rahmadani Putri , Mumuh Muharam , Rizki Wahyu Pratama   +3 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Sequential decentralized design of load frequency controllers in multiarea power systems

, 2003
A new systematic approach to design of sequential decentralized load frequency\ud controllers for multi-area power systems based on μ-synthesis is described.
Mitani, Yasunori, Bevrani, Hassan, Tsuji, Kiichiro   +2 more
core  

Amidst centralized and distributed frequency control in power systems

, 2016
We propose a novel frequency control approach in between centralized and distributed architectures, that is a generalized continuous-time feedback control version of the dual decomposition optimization method.
GRAMMATICO, SERGIO, Florian Dorfler, Sergio Grammatico, Dörfler, F., Grammatico, S, Dörfler, Florian, Dörfler, F, Grammatico, S.   +7 more
core   +1 more source

Review of Load Frequency Control in Wind Energy Conversion System

Wind
The integration of renewable energy sources (RESs) into modern power systems has introduced significant challenges in maintaining system stability and reliability.
Welcome Khulekani Ntuli, Musasa Kabeya
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source