Results 181 to 190 of about 4,744,882 (298)

Comparative Evaluation of the Efficacy of Triclosan-Coated and Chlorhexidine-Coated Suture on Bacterial Load Reduction in Periodontal Flap Surgery: A Clinicomicrobiological Study. [PDF]

J Pharm Bioallied Sci
Choudhary M, Bhatnagar S, Bagde H, Savitha AN, Radke V, Rathi R.   +5 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Strength gains and distinct acute blood lactate responses induced by stepwise load reduction training in healthy males. [PDF]

Front Physiol
Zeng Z, Zhou C, Yin W, Chen T, Han T, Xie Y, Zhou A.   +6 more
europepmc   +1 more source

Smoking load reduction is insufficient to downregulate miR-301b, a lung cancer promoter. [PDF]

Sci Rep, 2020
Dos Santos Arcas C, Lin-Wang HT, Umeda IIK, de Sousa MG, Utiyama DMO, de Padua Mansur A, Macchione M, Hirata MH, Nakagawa NK.   +8 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Study on load reduction and vibration control strategies for semi-submersible offshore wind turbines. [PDF]

Sci Rep
Bai D, Wang B, Li Y, Wang W.
europepmc   +1 more source

Waning of SARS-CoV-2 booster viral-load reduction effectiveness

, 2021
Levine-Tiefenbrun M, Yelin I, Alapi H, Herzel E, Kuint J, Chodick G, Gazit S, Patalon T, Kishony R.   +8 more
europepmc   +1 more source

Computational load reduction of the agent guidance problem using Mixed Integer Programming. [PDF]

PLoS One, 2020
Battagello VA, Soma NY, Afonso RJM.
europepmc   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Low- Versus High-Concentration Iodine Contrast for Hepatic Multiphase CT in Chronic Liver Disease: Image Quality, Lesion Detectability, and Iodine Load Reduction with Modern MDCT-A Retrospective Non-Inferiority Study. [PDF]

Diagnostics (Basel)
Kim BK, Kim JS, Lee HJ, Lee JK, Lee HA, Pak S.   +5 more
europepmc   +1 more source