Results 101 to 110 of about 874,596 (350)
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Physical Education of Students, 2016 Purpose: to determine characteristics of correlation of girl students’ and school girls’ subjective and physiological parameters of reaction to physical load.
Z.L. Kozina +6 more
doaj +1 more source
Incentive Regulation and Network Innovations [PDF]
Smart Grids require innovations in the electricity networks, mainly on the level of the distributed system operator (DSO). A main objective is to increase the share of distributed generation (DG) connected to that network level, but also to enable load ...
Dierk Bauknecht
core
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Peak-Load-Regulation Nuclear Power Unit Fault Diagnosis Using Thermal Sensors Combined with Improved ICA-RF Algorithm. [PDF]
Sensors (Basel), 2021 Wu Y, Wu K, Li W, Chen J, Yu Z.
europepmc +1 more source
Снижение энергонагруженности передних тормозных механизмов легковых автомобилей [PDF]
, 2011 Предложен способ регулирования тормозных сил между осями автомобиля, который приводит к выравниванию энергонагруженности тормозных механизмов передней и задней осей.Proposed method for braking forces regulation between automobile axes, which is lead ...
Назаров, А. И. +2 more
core
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
An Improved Voltage Regulation Performance of Floating Interleaved Boost Converters for Fuel Cell Applications Subject to Input Variation and Load Change [PDF]
, 2022 Manh Hung Nguyen, Kyoung Kwan Ahn
openalex +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source