Results 201 to 210 of about 874,596 (350)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Attachment as a Developmental Lens for Understanding Neurodivergence: A Clinical-Theoretical Proposal. [PDF]

Children (Basel)
Romeo VM.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A self-regulating fhan tracking differentiator algorithm of active disturbance rejection control. [PDF]

Sci Rep
Wang Z, Wang X, Bao X.
europepmc   +1 more source

Application of glucose load combined with subcutaneous injection of insulin indual-isotope myocardial metabolic imaging (DISA) blood sugar regulation

, 2015
刘建文, 耿亚琴
openalex   +1 more source

Enhancement of Load Voltage Regulation Using Electric Spring

, 2016
Benzeeta Ann D’Souza, Nagesh Prabhu
openalex   +1 more source

Functional MRI correlates of emotion regulation in major depressive disorder related to depressive disease load measured over nine years

, 2023
Rozemarijn S. van Kleef, Amke Müller, Laura S. van Velzen, Janna Marie Bas‐Hoogendam, Nic J.A. van der Wee, Lianne Schmaal, Dick J. Veltman, Maria M. Rive, Henricus G. Ruhé, Jan‐Bernard C. Marsman, Marie‐José van Tol   +10 more
openalex   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Appetite Regulation and Allostatic Load Across Prediabetes Phenotypes. [PDF]

Nutrients
Malin SK, Heiston EM.
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source