Results 81 to 90 of about 277,718 (342)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Optimizing Energy Consumption in Public Institutions Using AI-Based Load Shifting and Renewable Integration

Journal of Sensor and Actuator Networks
This paper details the development and implementation of an intelligent energy efficiency system for an electrical grid that incorporates renewable energy sources, specifically photovoltaic systems.
Otilia Elena Dragomir, Florin Dragomir, Marius Păun   +2 more
doaj   +1 more source

Load balancing with heterogeneous schedulers

, 2018
Load balancing is a common approach in web server farms or inventory routing problems. An important issue in such systems is to determine the server to which an incoming request should be routed to optimize a given performance criteria. In this paper, we assume the server's scheduling disciplines to be heterogeneous. More precisely, a server implements
Ayesta, Urtzi, Gupta, Manu K, Verloop, Ina Maria   +2 more
openaire   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Optimizing Smart Grid Demand Response: A Stackelberg Game Framework for Priority‐Aware Dynamic Pricing and Load Scheduling

Engineering Reports
Modern power systems face increasing complexity due to fluctuating demand and the intermittent nature of renewable energy sources. To address these challenges, this paper introduces a novel Stackelberg game‐theoretic framework for intelligent demand ...
Syed Ashraf Ali, Sohail Imran Saeed, Sanaullah Ahmad, Muhammad Waqas, Syed Haider Ali, Dilawar Shah, Shujaat Ali, Muhammad Tahir   +7 more
doaj   +1 more source

Scheduling Storms and Streams in the Cloud

, 2015
Motivated by emerging big streaming data processing paradigms (e.g., Twitter Storm, Streaming MapReduce), we investigate the problem of scheduling graphs over a large cluster of servers.
Ghaderi, Javad, Shakkottai, Sanjay, Srikant, R   +2 more
core   +1 more source

Optimal Day-Ahead Decision-Making Scheduling of Multiple Interruptible Load Schemes for Retailer With Price Uncertainties [PDF]

, 2021
Kai Wang, Ziwei Zhu, Zijun Guo
openalex   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Two-Layer Control Framework and Aggregation Response Potential Evaluation of Air Conditioning Load Considering Multiple Factors

IEEE Access
Air conditioning load has become a crucial demand response resource in power systems. However, due to its diversity in types and decentralized integration, the dispatch center faces challenges in directly accessing its aggregated power and conducting ...
Yixin Hou, Lin Zhao, Haiwei Jiang, Xing Ji, Jingzhi Zhao   +4 more
doaj   +1 more source