Results 71 to 80 of about 823,198 (305)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The Influence of the Load Model and other Parameters on the Dynamic Behavior of Curved-in-Plane Bridges

Curved and Layered Structures, 2016
This paper deals with the dynamic behavior of curved-in-plane bridges where the effect of the bridge curvature radius, the moving load (vehicle) speed, the truck cant angle, the deck surface conditions and, mainly, the response accuracy depending on the ...
Raftoyiannis Ioannis G., Michaltsos George T.   +1 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Tracking TCRß sequence clonotype expansions during antiviral therapy using high-throughput sequencing of the hypervariable region [PDF]

, 2016
To maintain a persistent infection viruses such as hepatitis C virus (HCV) employ a range of mechanisms that subvert protective T cell responses. The suppression of antigen-specific T cell responses by HCV hinders efforts to profile T cell responses ...
Arvind H Patel, Emma C Thomson, Gavin S Wilkie, John eMcLauchlan, Joseph eHughes, Mark W Robinson, Mark W Robinson, Peter R Mills, Rachael eSwann, Rachael eSwann, Stephen T Barclay   +10 more
core   +3 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Enhanced distance-based protection for high impedance faults considering dynamic load modelling

Results in Engineering
The load can be represented by different models, including static and dynamic representations; each has different responses when analysing a power system, which also impacts the protection system's performance.
D. Osorio-Vásquez, C. García-Ceballos, J. Mora-Flórez   +2 more
doaj   +1 more source

The crashworthiness performance of stacking sequence on filament wound hybrid composite energy absorption tube subjected to quasi-static compression load

Journal of Materials Research and Technology, 2020
This study investigates the energy absorption response of hybrid kenaf/glass fibre-reinforced epoxy when subjected to an axial quasi-static compression load with the effect of three stacking sequence of hybrid kenaf/glass reinforced epoxy.
Mohd Supian Abu Bakar, Mohd Sapuan Salit, Mohd Zuhri Mohamad Yusoff, Edi Syams Zainudin, Hamdan Haji Ya   +4 more
doaj   +1 more source

Effect of Glass Fiber Hybridization on the Behavior Under Impact of Woven Carbon Fiber/Epoxy Laminates [PDF]

, 2010
The low-velocity impact behavior was studied in hybrid laminates manufactured by RTM with woven carbon and glass (S2) fabrics. Specimens with different thicknesses and glass fiber content (from 0 to 21 vol.%) were tested with impact energies in the range
A. Enfedaque, Bartus, S.D., C. González, F. Gálvez, J. LLorca, J.M. Molina-Aldareguía, Reid, S.R.   +6 more
core   +2 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Bond Behavior of CFRP–Concrete Bonded Joints with Additional GFRP Layer: Effect of Bonding Sequence

Buildings
Existing studies have shown that bonding a ±45° biaxial GFRP under CFRP laminate can significantly improve the load-carrying capacity and ultimate deformation of CFRP–concrete bonded joints.
Hao Zhou, Jiahao Zhao, Yan Yang, Fengling Tan, Ya Ou, Yi Wang, Chao Li   +6 more
doaj   +1 more source