Results 81 to 90 of about 823,198 (305)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Mitigation of harmonics and unbalanced source voltage condition in standalone microgrid: positive sequence component and dynamic phasor based compensator with real-time approach

Heliyon, 2019
Penetration of Distributed Energy Resources (DER) is in high demand to supply power to the load where the grid is not available. Many of these sources are a single phase source used to form standalone Microgrid (MG).
M. Rane, S. Wagh
doaj   +1 more source

Statistical characterization of the fatigue behavior of composite lamina [PDF]

A theoretical model was developed to predict statistically the effects of constant and variable amplitude fatigue loadings on the residual strength and fatigue life of composite lamina.
Jones, D. L., Yang, J. N.
core   +1 more source

Experimental and analytical study of cracks under biaxial fatigue [PDF]

, 2016
Most mechanical components experience multi-axial cyclic loading conditions during service. Experimental analysis of fatigue cracks under such conditions is not easy and most works tend to focus more on the simpler but less realistic case of uni-axial ...
Camas, Daniel, Lopez-Crespo, Pablo, Lopez-Moreno, A, Mokhtarishirazbad, M, Moreno-Morales, Maria Belen, Zanganeh, M   +5 more
core  

Spontaneous thermal expansion of nematic elastomers

, 2001
We study the monodomain (single-crystal) nematic elastomer materials, all side-chain siloxane polymers with the same mesogenic groups and crosslinking density, but differing in the type of crosslinking.
Tajbakhsh, A. R., Terentjev, E. M.
core   +1 more source

FPGA-based implementation of the back-EMF symmetric-threshold-tracking sensorless commutation method for brushless DC-machines [PDF]

, 2013
The operation of brushless DC permanent-magnet machines requires information of the rotor position to steer the semiconductor switches of the power-supply module which is commonly referred to as Brushless Commutation. Different sensorless techniques have
Darba, Araz, De Belie, Frederik, Melkebeek, Jan, Salem Mohamed Salem, Aboubakr   +3 more
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Effect of ordering of cyclic loading sequences on the short-term performance of offshore monopiles in an overconsolidated clay

Applied Ocean Research
Wind and wave actions that vary in amplitude, frequency and direction cause irregular cyclic loading on monopiles supporting offshore wind turbines (OWTs), resulting in cumulative deformation.
Iwinosa O. Aghedo, Mohamed Rouainia
doaj   +1 more source

Visual mismatch negativity in the dorsal stream is independent of concurrent visual task difficulty

Frontiers in Human Neuroscience, 2013
The manipulation of attention can produce mismatch negativity-like components that are not necessarily connected to the unintentional sensory registration of the violation of probability-based regularity. For clinical purposes, attentional bias should be
Jan eKremlacek, Miroslav eKuba, Zuzana eKubová, Jana eLangrová, Jana eSzanyi, František eVít, Michal eBednar   +6 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source