Results 121 to 130 of about 469,258 (281)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

PRETZEL: Opening the Black Box of Machine Learning Prediction Serving Systems

, 2018
Machine Learning models are often composed of pipelines of transformations. While this design allows to efficiently execute single model components at training time, prediction serving has different requirements such as low latency, high throughput and ...
Chun, Byung-Gon, Interlandi, Matteo, Lee, Yunseong, Santambrogio, Marco Domenico, Scolari, Alberto, Weimer, Markus   +5 more
core  

Bearing behaviors of rock-socketed piles in layered dynamically compacted soil-rock mixtures: A case study

Alexandria Engineering Journal
After layered dynamic compaction (DC) treatment in a mountainous area with deep backfill in Chongqing, China, a series of pile tests and analyses were conducted to evaluate the vertical bearing capacity of rock-socketed piles and to investigate their ...
Yingjie Wei, Mengyao Zhao, Yong Zeng, Yuyou Yang, Huancun Liu, Jianguang Li, Yuxin Jie   +6 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Study on the Dynamic Performance of Planetary Gear Transmission System of the MW Level Wind Power Speed-growth Gearbox

Jixie chuandong, 2015
The load sharing planetary gear speed-growth train for wind power generator is studied,which is composed of two stage planetary gear and one stage plane gear.The influence of external load excitation and time varying mesh stiffness is considered,and the ...
Wang Chunguang
doaj  

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Research on Improving Energy Efficiency Through Optimal Load Control Between a Ship’s Shaft Generator and Diesel Generator

IEEE Access
In response to the escalating climate change crisis, the International Maritime Organization has implemented stringent regulations to significantly improve the energy efficiency of ships.
Heemoon Kim, Jongsu Kim
doaj   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Analysis of load sharing characteristics of the thermoelastic coupled coaxial face gear power split transmission system

Jixie chuandong
ObjectiveTaking a coaxial face gear power split transmission system as the research object, the influence of gear thermal deformation induced by the temperature field on stiffness and backlash was considered, and a combined approach of analytical method ...
LIU Li, GUO Hui, ZHAO Ning
doaj