Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Total and partial knee arthroplasty implants that maintain native load transfer in the tibia. [PDF]
Bone Joint Res, 2022 Munford MJ +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Parametric Studies of the Load Transfer Platform Reinforcement Interaction with Columns. [PDF]
Materials (Basel), 2021 Gajewska B, Gajewski M, Lechowicz Z.
europepmc +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Diance yu yibiaoThe research on uninterrupted loop-closing load transfer in distribution network is of great significance to ensure the high requirements for power quality and supply reliability in industrial production and residential electricity.
LI Qian +5 more
doaj +1 more source
Plantar load transfer in children: a descriptive study with two pathological case studies. [PDF]
BMC Musculoskelet Disord, 2021 Brierty A +6 more
europepmc +1 more source
Development of a laser-induced heat flux technique for measurement of convective heat transfer coefficients in a supersonic flowfield [PDF]
A technique is developed to measure the local convective heat transfer coefficient on a model surface in a supersonic flow field. The technique uses a laser to apply a discrete local heat flux at the model test surface, and an infrared camera system ...
Chriss, Randall M. +4 more
core +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
The load transfer effect of monopolar and bipolar radial head prosthesis designs on capitellar cartilage: A comparative biomechanical cadaver study. [PDF]
Acta Orthop Traumatol Turc, 2022 Aşık MO +5 more
europepmc +1 more source