Results 121 to 130 of about 3,910,937 (245)
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Advances in Civil EngineeringThe mechanism of soil arching is a critical technical issue in the load transfer of geosynthetic-reinforced pile-supported (GRPS) embankments. To investigate the evolution of soil arching under high-speed railway loading within a pile group system, a ...
Min Geng, Junqiang Cui, Zhihui An
doaj +1 more source
AgricultureMachine-harvested seed cotton was taken as the research object to further clarify its creep performance, minimize its power consumption during the loading process, and obtain a better loading method.
Ximei Wei +6 more
doaj +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Editorial -- Game Studies In Media Res: Beginning From The Middle-State
, 2015 Editorial introduction to this special guest-edited issue of ...
Wilcox, Steve, Hancock, Michael
core
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Influence of Loading Frequency on Fatigue Properties of Structural Materials
, 2008 This thesis analyse the influence of loading frequency on the fatigue of the structural materials. Low frequency loading (to the 200 Hz) has nearly no influence on the fatigue properties in almost all cases.
Kašpar, Jan
core
Double dominant frequency of microseismic signal and micro-fracture mechanism of granite rockmass
Geomechanics and Geophysics for Geo-Energy and Geo-ResourcesMicroseismic monitoring plays a pivotal role in understanding rock fracture mechanisms in engineering. This study integrates laboratory-scale acoustic emission experiments with engineering -scale microseismic monitoring to examine the double dominant ...
Sihong Chen +6 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source