Results 141 to 150 of about 832,826 (306)
“You’re Getting to be a Habit with Me”: Diegetic Music, Narrative, and Discourse in Bioshock
, 2018 This article examines how diegetic music in Bioshock (2007) is an explicit component of narrative production, game environment creation, and player immersion.
Yanez, Rodrigo Pablo
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Surface-water contamination from agricultural chemicals is a problem in northeast Kansas. The objective of this study is to compare potential atrazine, nitrogen, and sediment loadings from regional conventional and alternative cropping systems.
Diebel, Penelope L., Koo, Seungmo
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SCALE LEVELS OF SHEAR INSTABILITY IN SOLIDS UNDER LOADING
Journal of the Mechanical Behavior of Materials, 2000 Panin, V.E.
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
MODELLING OF STRESS GRADIENT EFFECT ON FATIGUE LIFE USING WEIBULL BASED DISTRIBUTION FUNCTION [PDF]
, 2013 In the present paper, a new approach is developed in order to take into account the stress gradient effect on fatigue life of structural components. The proposed approach is based on the weakest link concept in which the shape coefficient of the Weibull ...
PALIN-LUC, Thierry +2 more
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Shear behaviour of rock joints under cyclic loading and constant normal stiffness conditions [PDF]
, 2013 Shear behaviour of rock joints subjected to cyclic loading was previously studied mostly under Constant Normal Load (CNL) conditions which does not accurately simulate the actual deformation behaviour of field rock joints. Natural joints are often filled
Mirzaghorbanali, Ali
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