Results 41 to 50 of about 81,646 (345)

Structure‐Guided Engineering of a Promiscuous O‐Methyltransferase for a SAM Regeneration Biocatalysis Platform of Methylated Pharmaceuticals

Advanced Science, EarlyView.
A substrate promiscuous and regioselective O‐methyltransferase, SmOMT, is functionally and structurally characterized. A double mutant, SmOMTE152A/I306A, exhibited enhanced catalytic activity. By coupling this mutant with a mutant halide methyltransferase, AtHMTV140T, for SAM regeneration, a superior artificial fusion enzyme, AtHMTV140T‐L95‐SmOMTE152A ...
Xiran Xiong, Jun Song, Shihan Li, Lu Jin, Qi He, Baohui Zhang, Yan Cao, Shanyong Yi, Yanfang Yang, Xiang Li, Juan Li, Wei Huang   +11 more
wiley   +1 more source

O legislativo como arena de interesses organizados: a atuação dos lobbies empresariais

Locus, 1999
Na esteira das reformas do Estado, este trabalho analisa o papel do Legislativo como uma arena para articulação de interesses empresariais com a desarticulação dos canais que vinculavam a estrutura de representação do setor privado diretamente ao ...
Eli Diniz, Renato Boschi
doaj  

Selectivity Filter Dynamics Define Ion Conductance and Selectivity Differences in CNG and HCN Channels

Advanced Science, EarlyView.
Cyclic nucleotide‐gated (CNG) and hyperpolarization‐activated cyclic nucleotide‐gated (HCN) channels share substantial sequence and structural similarity but differ markedly in ion conductance and K+ selectivity. Microsecond‐scale atomistic MD simulations qualitatively reproduced the conductance differences observed in single‐channel recordings and ...
Haoran Liu, Klaus Benndorf, Yessenbek K. Aldakul, Han Sun   +3 more
wiley   +1 more source

Compensatory Interplay Between Clarin‐1 and Clarin‐2 Deafness‐Associated Proteins Governs Phenotypic Variability in Hearing

Advanced Science, EarlyView.
Functional compensation between clarin‐1 and clarin‐2 in cochlear hair cells. Hearing loss associated with CLRN1 mutations shows striking phenotypic variability; however, the underlying mechanisms remain poorly understood. This study reveals that clarin‐1 and clarin‐2 function cooperatively in cochlear hair cells to sustain mechanoelectrical ...
Maureen Wentling, Aïda Yakhlef Sanchez, Nicolas Thelen, Müge Senarisoy, Maria Hogg, Steven Condamine, Andrea Lelli, Emilia Wysocka, Pranav Patni, Sandrine Vitry, Kerem Yasin Yildizhan, Sébastien Le Gal, Sylvie Nouaille, Michael R. Bowl, Marc Thiry, Didier Dulon, Sedigheh Delmaghani, Aziz El‐Amraoui   +17 more
wiley   +1 more source

Engineering Na‐Rich P2‐Type Layered Oxides Through Li/Ti Dual Doping for Oxygen Redox Activation and Superior Structural Stability

Advanced Energy Materials, EarlyView.
P2‐type sodium layered oxides have potential for high‐voltage operation but suffer from structural instability and capacity fading. This work demonstrates that synergistic Li and Ti co‐doping enhances sodium inventory, suppresses detrimental phase transitions, and activates reversible lattice oxygen redox.
Rishika Jakhar, Shrestha Ghosh, Adesh Rohan Mishra, Shristi Pradhan, Debalina Sarkar, Yuanlong Bill Zheng, Zengqing Zhuo, Tianyi Li, Lu Ma, Minghao Zhang, Shyue Ping Ong, Matthew Li, Leeann Sun, Prabhat Thapliyal, Jing Wang, Abhik Banerjee, Ying Shirley Meng   +16 more
wiley   +1 more source

Pouvoir et gouverner : le cas du syndicalisme aux États-Unis

Cahiers du MIMMOC, 2014
For several years, U.S. labor in the private sector has undergone an obvious decline. In addition to employers' organizations, various states' and federal legislations have been responsible for this decline. This article describes U.S.
Daniel PELTZMAN
doaj   +1 more source

Impact of Extrusion and Direct Calendering on Dry‐Coated Cathodes for Sulfidic All‐Solid‐State Batteries

Advanced Energy Materials, EarlyView.
This work demonstrates a parameter optimization for a scalable dry coating process of sulfidic ASSB cathodes (82 wt% CAM, 0.5 wt% PTFE binder) in dry room atmosphere. High‐shear extruder mixing and calendering are used to form a cathode film based on PTFE fibrillation.
Michael Wolf, Benjamin vom Hau, Rebecca Wilhelm, Matti M. Kaye, Aaron Stoeckle, Johannes Kriegler, Florian Schmidt, Stefan Stojcevic, Korbinian Huber, Simon Lux   +9 more
wiley   +1 more source

Researching Illegal Logging and Deforestation

International Journal for Crime, Justice and Social Democracy, 2014
Tropical deforestation such as in the Amazon can be studied well from a green criminological perspective. Ethnographic research methods form a useful way to get insight into the dynamics and complexity of tropical deforestation, which often is illegal ...
Tim Boekhout van Solinge
doaj   +1 more source

Changes in Alcohol Retail Laws and Foot Traffic at Liquor Stores

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT We study how expanding alcohol availability at grocery and convenience stores affects consumer traffic in liquor stores by leveraging recent changes in state‐level alcohol distribution laws in a difference‐in‐difference quasi‐experimental design.
Nathan Palardy, Marco Costanigro, Joshua Berning, Jude Bayham   +3 more
wiley   +1 more source

Indirect Lobbying and Media Bias [PDF]

In this paper, we study a model where voters have state-contingent preferences over policies and lobbies engage in influence activities to affect the information that a media outlet collects on the state of the world.
Sobbrio, Francesco
core   +1 more source