Results 231 to 240 of about 908,499 (354)

Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression

Advanced Science, EarlyView.
In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi, Zesheng Li, Xin Sun, Yanfeng Yang, Yumin Luo, Ziang Song, Hengxin Dong, Lei Jin, Jing Xie, Yongzhi Shan, Guoguang Zhao   +10 more
wiley   +1 more source

Establishing an in vivo large animal model of one-lung ventilation and operative lung trauma. [PDF]

PLoS One
Giffin C, Kormish J, Hinton M, Dakshinamurti S, Graham R, Kidane B.   +5 more
europepmc   +1 more source

RIPK1 Drives JAK1‐STAT3 Signaling to Promote CXCL1‐Mediated Neutrophil Recruitment in Sepsis‐Induced Lung Injury

Advanced Science, EarlyView.
This article examines the central role of RIPK1 in the pathogenesis of sepsis‐induced lung injury. It elucidates how RIPK1 initiates an inflammatory cascade by activating JAK1‐STAT3 signaling, leading to CXCL1‐mediated neutrophil infiltration. Importantly, it demonstrates that pharmacological inhibition of RIPK1 effectively attenuates inflammation and ...
Hao Sun, Xiya Li, Shenjia Gao, Yi Jiang, Xinyi Wu, Zhaoyuan Chen, Han Wu, Qing Hua, Rui Zu, Huaijiang Xiang, Ronen Ben‐Ami, Changhong Miao, Li Tan, Ying Li, Jun Wang, Wankun Chen   +15 more
wiley   +1 more source

Stichwort: Forschung in der wissenschaftlichen Weiterbildung

Zeitschrift Hochschule und Weiterbildung, 2017
Wolfgang Jütte, Claudia Lobe
doaj   +1 more source

Cystic Intraductal Papillary Neoplasm of the Bile Duct in the Left Lobe of the Liver With Associated Liver Atrophy: A Case Report. [PDF]

Clin Case Rep
Jaishi S, Deo KB, Yogi BR, Agrawal Y, Lamichhane S, Adhikary S.   +5 more
europepmc   +1 more source

Riedel's Lobe and Hepatoptosis Giving Rise to Difficulty in Diagnosis

, 1935
F. Parkes Weber, Andreas Schlüter
openalex   +1 more source

LESIONS OF THE PRE-FRONTAL LOBES AS A CAUSE OF MOTOR SYMPTOMS ON THE SAME SIDE. [PDF]

, 1891
F.W. Jollye
openalex   +1 more source

Succinic Acid‐Induced Macrophage Endocytosis Promotes Extracellular Vesicle‐Based Integrin Beta1 Transfer Accelerating Fibroblast Activation and Sepsis‐Associated Pulmonary Fibrosis

Advanced Science, EarlyView.
Lipopolysaccharide (LPS) stimulates the production of succinic acid in lung tissue, which promotes macrophages endocytosis and the formation of multivesicular bodies (MVBs). These MVBs release profibrotic extracellular vesicles (EVs), facilitating the transfer of integrin beta1 (ITGβ1) transfer and subsequently activating fibroblasts, thereby ...
Wenyu Yang, Ri Tang, Yang Zhou, Jinquan Zhang, Shuya Mei, Yawen Peng, Xi Huang, Shunpeng Xing, Yuan Gao, Qiaoyi Xu, Zhengyu He   +10 more
wiley   +1 more source

Trends in der Akteurslandschaft der wissenschaftlichen Weiterbildung

Zeitschrift Hochschule und Weiterbildung, 2016
Claudia Lobe, Markus Walber
doaj   +1 more source

Pulmonary Artery Stenting for Widespread Distal Congenital Stenoses. [PDF]

JACC Case Rep
Wiltshire S, Collins F, Kotlyar E, Kearney K, Lau E, Macdonald P, Boshell D, Cordina R.   +7 more
europepmc   +1 more source