Results 251 to 260 of about 908,499 (354)

Targeting ROCK2 to Restore Epileptic Synaptic Networks via Mitophagy Activation: Insights from Translational Imaging of SV2A In Vivo

open access: yesAdvanced Science, EarlyView.
By integrating synaptic vesicle glycoprotein 2A PET imaging and transcriptomics, this study identifies Rho‐associated protein kinase 2 (ROCK2) as a critical regulator of synaptic network dysfunction in temporal lobe epilepsy. Pharmacological ROCK2 inhibition restores synaptic density and enhances mitophagy, thereby reducing seizures and neuronal damage.
Ling Xiao   +14 more
wiley   +1 more source

A novel role for Hsc70-4 in blood cell differentiation in <i>Drosophila</i>. [PDF]

open access: yesFront Immunol
Kharrat B   +4 more
europepmc   +1 more source

Integrin αvβ6‐Targeted PET/CT Imaging of Non‐Small Cell Lung Cancer with [68Ga]Ga‐Trivehexin: Improved Preoperative Lymph Node Staging and Association with Immunohistochemistry

open access: yesAdvanced Science, EarlyView.
Integrin αvβ6‐targeted [68Ga]Ga‐Trivehexin positron emission tomography/computed tomography (PET/CT) can accurately identify regional lymph nodes and cerebral metastases in non‐small cell lung cancer (NSCLC) compared with 2‐deoxy‐2‐[18F]fluoro‐D‐glucose ([18F]FDG).
Huiqin Wu   +9 more
wiley   +1 more source

The value of relative CT attenuation in predicting invasiveness in patients with T1-stage lung adenocarcinoma. [PDF]

open access: yesQuant Imaging Med Surg
Shi W   +17 more
europepmc   +1 more source

Highly‐Polarized Near‐Infrared Photodetector Based on 2D Organic/Inorganic Van Der Waals Heterostructure

open access: yesAdvanced Science, EarlyView.
Employing 2D organic/inorganic van der Waals heterostructure, a highly sensitive polarized near‐infrared photodetector is fabricated. This device demonstrates exceptional visible and NIR detection capabilities, achieving a responsivity as high as 104 A W−1.
Wen Xu   +6 more
wiley   +1 more source

Auftakt für ein Berichtssystem in der wissenschaftlichen Weiterbildung

open access: yesZeitschrift Hochschule und Weiterbildung, 2015
Claudia Lobe   +2 more
doaj   +1 more source

Metabolic Interplay in Acute Lung Injury: PARK7 Integrates FADS1/2‐Dependent PUFA Metabolism and H3K14 Lactylation to Attenuate Endothelial Ferroptosis and Dysfunction

open access: yesAdvanced Science, EarlyView.
SCAP/ARDS patients show reduced unsaturated fatty acids (UFAs) but higher PARK7 and lactate in plasma. PARK7 correlates positively with lactate and negatively with UFAs. Pulmonary endothelial cell multi‐omics show FADS1/2 downregulation and impaired PUFA metabolism. Lactate boosts PARK7 via H3K14 lactylation, and PARK7 then restores FADS1/2.
Jian Xu   +11 more
wiley   +1 more source

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