Results 271 to 280 of about 908,499 (354)

Lactate Metabolic Reprogramming Mediated by CircRNA–LDHA Complex Facilitates Innate Immune Evasion of Liver Cancer

open access: yesAdvanced Science, EarlyView.
CircSMPD4 physically combines with lactate dehydrogenase A (LDHA) and reduces its acetylation level via SIRT2‐dependent deacetylation, thereby inhibiting chaperone‐mediated autophagy‐lysosome degradation of LDHA. Upregulating LDHA leads to increasing lactate production and extracellular export, which in turn suppresses natural killer cell cytotoxicity ...
Hao Shen   +16 more
wiley   +1 more source

Revealing the Character of Coordination Bonding in 2D Metal–Organic Frameworks

open access: yesAdvanced Science, EarlyView.
Photoemission‐derived momentum maps and density functional theory calculations show the re‐appearance of frontier molecular orbital patterns at two distinct binding energies, a result of the formation of bonding and antibonding states below the Fermi edge from covalent hybridisation with the metal centres.
Dominik Brandstetter   +7 more
wiley   +1 more source

CT-guided preoperative localization of nonpalpable pulmonary lesions with a specifically designed device: evaluation of safety and efficacy. [PDF]

open access: yesEinstein (Sao Paulo)
Melo RAB   +5 more
europepmc   +1 more source

Lactate‐Modulating Nanoreactors Facilitate Self‐Amplifying Pyroptosis and the cGAS‐STING Cascade for Potentiated Catalytic‐Immunotherapy

open access: yesAdvanced Science, EarlyView.
An intelligent lactate‐depleting LOCoF2 (CoF2@LOx) nanoreactor system is developed to effectively induce self‐reinforced pyroptosis and activate the cGAS‐STING signaling pathway, thereby inducing a strong immune response and enhancing the therapeutic effectiveness of catalytic immunotherapy.
Linzhu Zhang   +10 more
wiley   +1 more source

Assessing the Nature of Human Brain‐Derived Extracellular Vesicles on Synaptic Activity Via the Development of an Air‐liquid Microfluidic Platform

open access: yesAdvanced Science, EarlyView.
This seminal study highlights the interwoven and tightly regulated functions of brain‐derived extracellular vesicles. Using microfluidics, proteomics, and AI‐based electric signal analyses of cortical brain explants, this work provides a useful resource dataset revealing the composition of human brain‐derived extracellular vesicles obtained from ...
Corentin Bernou   +14 more
wiley   +1 more source

Beyond infection: Ommaya reservoir-induced vasogenic edema and reversible leukoencephalopathy. [PDF]

open access: yesOxf Med Case Reports
Fadil M   +5 more
europepmc   +1 more source

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