Results 281 to 290 of about 908,499 (354)

A Mathematical Model of Cellular Aggregation Predicts Patterns of Tau Accumulation in Neurodegenerative Disease

Advanced Science, EarlyView.
A minimal computational model of cellular aggregate formation in neurodegenerative disease, encompassing two competing processes: cell‐autonomous and cell‐to‐cell triggers of aggregation, is presented. Despite its simplicity, the model can reproduce the aggregate patterns observed in post‐mortem brain images from the primary tauopathy Progressive ...
Shih‐Huan Huang, Annelies Quaegebeur, Tanrada Pansuwan, Timothy Rittman, Ruiyan Wang, Tuomas PJ Knowles, James B Rowe, David Klenerman, Georg Meisl   +8 more
wiley   +1 more source

Stichwort: Strukturen wissenschaftlicher Weiterbildung

Zeitschrift Hochschule und Weiterbildung
Claudia Lobe, Mandy Schulze
doaj   +1 more source

Case Report: Pathological diagnosis of left upper lobe nodules: two cases of composite small cell lung cancer and literature review. [PDF]

Front Oncol
Zhang J, Jin D, Wei Y.
europepmc   +1 more source

Molecular Insights into Fungal Glycosylphosphatidylinositol Transamidase Complex

Advanced Science, EarlyView.
The glycosylphosphatidylinositol (GPI) biosynthesis pathway is critical for antifungal drug development. This study reports three cryo‐electron microscopy structures of fungal GPI transamidase (GPIT), captured in two substrate‐bound states and a novel dimeric assembly.
Zhengkang Hua, Xuyang Ding, Yanan Wu, Di Zhang, Xinlin Hu, Ping Yang, Jiameng Li, Yi Tan, Junbo Liu, Mingjie Zhang, Min Zhang, Xiaotian Liu, Hongjun Yu   +12 more
wiley   +1 more source

Temporal Lobe Epilepsy With GAD Antibodies-Time to Give Up, or Time to Double Down? [PDF]

Epilepsy Curr
Steriade C.
europepmc   +1 more source

Red Blood Cell‐Derived Exosomal miR‐93‐5p Promotes Lung Cancer Progression through PTEN Suppression

Advanced Science, EarlyView.
Red blood cell (RBC)‐derived exosomal miR‐93‐5p is elevated in lung cancer patients and correlates with poor outcomes. Exosomal miR‐93‐5p suppresses PTEN in cancer cells, enhancing proliferation, migration, and invasion. In mouse models, therapeutic inhibition with ASO‐miR‐93 5p reduces tumor growth, highlighting a bidirectional tumor‐RBC‐tumor axis ...
Ning Li, Pushpa Dhilipkannah, Van K Holden, Ashutosh Sachdeva, Feng Jiang   +4 more
wiley   +1 more source

Preservation of parathyroid vascularization in thyroid surgery: morphological study and surgical implications. [PDF]

Surg Radiol Anat
Melo C, Bernardes A, Cardoso L, Miguéis A.   +3 more
europepmc   +1 more source

The Crosstalk Between CRL5 and APC/C E3 Ligases Regulates Metastasis and Chemosensitivity of Cancer Cells

Advanced Science, EarlyView.
This study uncovers a previously unknown crosstalk between two major ubiquitin ligases, CRL5 and APC/C. The authors identify APC11 as a binding partner of CUL5, showing that their interaction regulates neddylation, substrate stability, and mitotic progression.
Danrui Cui, Ruirui Qu, Tianqi Li, Linchen Wang, Xiaoyu Chen, Shengpeng Shao, Xue Liang, Jun Xu, Yi Sun, Xiufang Xiong, Yongchao Zhao   +10 more
wiley   +1 more source

A case of tuberculosis in the cavitary lesion suggestive of neoplasm. [PDF]

Rev Soc Bras Med Trop
Altınkaya C, Karaman A.
europepmc   +1 more source

SpaBalance: Balanced Learning for Efficient Spatial Multi‐Omics Decoding

Advanced Science, EarlyView.
SpaBalance is a computational framework that harmonizes multi‐omics learning via gradient equilibrium and dual‐stream feature decomposition, achieving superior clustering accuracy, biological interpretability, and scalable integration of three or more spatial omics modalities.
Yingbo Cui, Yong Zhao, Canqun Yang, Tao Tang, Xiangke Liao, Hongyu Zhang, Huiying Zhao, Zheng Wang, Yuansong Zeng   +8 more
wiley   +1 more source