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Lobular Carcinoma In Situ

2019
Lobular carcinoma in situ (LCIS) is a high-risk atypical breast lesion associated with an increased risk of breast cancer in either breast. It is most often found incidentally during a breast biopsy. Management of classis LCIS focuses first on confirming radiology-pathology concordance for the imaging abnormality that was biopsied.
Anjali R. Thawani, Lillian M. Erdahl
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Lobular carcinoma in situ and invasive lobular cancer of the breast

Current Opinion in Obstetrics and Gynecology, 2005
The incidence of lobular carcinoma in situ and invasive lobular carcinoma of the breast is increasing. Recent data suggest that lobular carcinoma in situ is an indolent precursor for breast cancer, rather than a pure risk factor. This could imply free surgical margins become important.
Veronique, Cocquyt, Simon, Van Belle
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Lobular Carcinoma in Situ

Surgical Oncology Clinics of North America, 1993
Lobular carcinoma in situ (LCIS) differs in important ways from duct carcinoma in situ (DCIS). Most importantly, LCIS is not considered an early stage of breast cancer, but rather a marker of risk for subsequent cancer development, equal in either breast and requiring lifetime follow-up.
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Prognostic Value of Coexisting Lobular Carcinoma In Situ With Invasive Lobular Carcinoma

Applied Immunohistochemistry & Molecular Morphology, 2016
Aims and Objectives: Recent studies show that lobular carcinoma in situ (LCIS) and invasive lobular carcinoma (ILC) share similar genetic molecular biology. There are increasing concerns regarding the biological significance of LCIS.
Aparna, Harbhajanka   +7 more
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[Lobular carcinoma in situ and lobular cancer (lobular carcinoma) of the breast].

Arkhiv patologii, 1977
The histological characterization of mammary cancer (MC) is of leading importance for prognosis and choice of therapeutic methods (directed hormonal and chemotherapy). In this respect of interest is the morphological picture of a special form of MC, lobular cancer which is characterized by the most malignant course, marked infiltrative and less ...
Z V, Gol'bert, E E, Sorkin
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The Continuing Dilemma of Lobular Carcinoma In Situ

Archives of Surgery, 1992
We reviewed the courses of 250 consecutive women with lobular carcinoma in situ of the breast entered into the Surveillance, Epidemiology, and End Results program of the Michigan Cancer Foundation, Detroit, Mich, between 1973 and 1986. No patient had known invasive cancer at the time of initial entry. The average follow-up was 93.1 months; 212 patients
A J, Walt, M, Simon, G M, Swanson
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Lobular Carcinoma “in Situ” (Lobular Neoplasia)

1986
Lobular carcinoma “in situ” or lobular neoplasia (Haagensen et al., 1978) is a non-palpable tumor which can only be diagnosed under the microscope (fig. 1 and 2). Histologically, the terminolobular units are densely filled with loosely adherent tumor cells which distend the lobules and increase their diameter.
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Current treatment for lobular carcinoma in situ

Annals of Surgical Oncology, 1998
We thought that observation for patients with lobular carcinoma in situ (LCIS) had been generally accepted by the mid-1980s. A questionnaire mailed to oncologic surgeons in 1988 revealed that 33% of the respondents still advised unilateral mastectomy, although a slim majority (54%) advised observation. New studies have been published in the intervening
F E, Gump, D, Kinne, G F, Schwartz
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In Situ Lobular Carcinoma

1984
Lobular carcinoma in situ was first described as a distinct entity by Foote and Stewart in 1941 1, although there is still considerable controversy concerning the true nature of the lesion and the most appropriate terminology. Haagensen and colleagues2 consider the lesion to be precancerous and call it simply ‘lobular neoplasia’, while Toker and ...
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Atypical Lobular Hyperplasia and Lobular Carcinoma In Situ

2016
Atypical lobular hyperplasia (ALH) and lobular carcinoma in situ (LCIS) are lobular intraepithelial neoplasms that are often grouped under the term lobular neoplasia (LN). The pathognomonic feature of LN is discohesion secondary to absence or dysfunction of E-cadherin.
Helena Hwang, Sunati Sahoo
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