Results 21 to 30 of about 17,147,784 (231)
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Theoretical and methodological reflection of a case study on the Deblínsko landscape project
Envigogika, 2015 Full text of the article is available both in English and Czech. The case study is based primarily on long-standing collaboration of two public sector institutions: the MU in Brno and the Deblín Primary School and Kindergarten, with cooperation of ...
Alois Hynek +3 more
doaj +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Challenges of Poverty: Parents' voices [PDF]
, 2017 The Child Poverty Action Group Early Warning System (EWS) gathers information and case studies about the impact of welfare reform on children and families across Scotland. This EWS short report is published as part of Challenge Poverty Week 2017 to
Treanor, Morag +2 more
core
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
A LOCAL DEVELOPMENT PROJECT IN THE FRAMEWORK OF PUBLIC POLICIES FOCUSED ON REGIONAL DEVELOPMENT STRATEGIES [PDF]
Risk in Contemporary Economy, 2013 This paper aims at outlining a successful implementation of a project within LEADER framework, which is a local development method which allows local actors to develop an area by using its endogenous development potential.
George Schin
doaj
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Antea Group Archeologie 2020/137
, 2022 In juli en september 2020 heeft Antea Group in opdracht van BNVB Projects B.V. een archeologisch onderzoek uitgevoerd voor het plangebied ‘Grutterij 7-9’ te Amstelveen, gemeente Amstelveen.
Looveren, V. van (Antea Group)
core +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Littera Scripta, 2016 This paper presents the opportunities for using local action groups (LAG) as an ideal platform for the initiation of the functional and long-term development of rural regions.
Petra Pártlová, Jan Hron
doaj