Results 151 to 160 of about 6,228,010 (302)

In Situ Genetic Engineering Facilitates MMP‐9‐Responsive TIMP1 Release Through Proteolytic Cleavage to Boost Diabetic Wound Healing

Advanced Science, EarlyView.
This study develops an MMP‐9‐responsive protein release system that transforms resident cells into drug depots through in situ genetic engineering. Anchored to the membrane, the therapeutic protein TIMP1 is selectively released upon MMP‐9 cleavage.
Yuan Zhang, Jiani Deng, Man Yee Cheung, Tingting Fu, Xufeng Qi, Dongqing Cai, Jianmin Sun, Gang Lu, Peng Shi, Wai‐Yee Chan, Xu Li, Hui Zhao   +11 more
wiley   +1 more source

Interpreting cranial abdominal coverage after caudal epidural local anesthetic administration in dogs and cats. [PDF]

Front Vet Sci
Nagahama S.
europepmc   +1 more source

Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)‐Linked Neuroinflammation

Advanced Science, EarlyView.
Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn, Wenjing Wang, Yao Qin, Lili Yan, Stephan Scheeff, Xu He, Qiong Wu, Yue Lin, Jinsai Shang, Xin Ye, Jing Liu, Kailei Sun, Chun Wai Yeung, Junzhe Huang, Zhenghui Chen, Xiaodong Liu, Yiqun Geng, Shannon Wing Ngor Au, Bonaventure Y. Ip, Ho Ko, Billy Wai‐Lung Ng   +20 more
wiley   +1 more source

Enhanced Pain Management With Combined EMLA Patch and Local Anesthetic Infiltration in Transradial Angiography. [PDF]

Clin Cardiol
Nashtar MA, Azizy O, Trippe J, Canbay A, Patsalis PC, Steinmetz M.   +5 more
europepmc   +1 more source

Single‐Cell Dissection of Microglial Dysfunction in Diabetes‐Associated Neurodegenerative Vulnerability

Advanced Science, EarlyView.
Using single‐cell transcriptomic and epigenomic profiling, researchers mapped microglial dysfunction across the lifespan of db/db mice. The authors uncovered a nonlinear microglial remodeling featuring early inflammatory priming, a mid‐stage transcriptional inflection, and late dysfunction.
Jizhou Zhang, Tsz Kwan Yau, Joyce Tse, Tsz Ho Li, Dongjie Hu, Yong Juan Zhao, Ting‐Fung Chan   +6 more
wiley   +1 more source

Design and Application of Intelligent Local Anesthetic Nanoformulations. [PDF]

Pharmaceutics
Ke P, Li Y, Han M, Wu X.
europepmc   +1 more source

SYNTHESES AND LOCAL ANESTHETIC ACTIVITY OF SUBSTITUTED BENZOATES OF ORTHO-((N,N)-DIALKYLAMINOMETHYL)BENZYL ALCOHOLS.

, 1971
SYNTHESES AND LOCAL ANESTHETIC ACTIVITY OF SUBSTITUTED BENZOATES OF ORTHO-((N,N)-DIALKYLAMINOMETHYL)BENZYL ...
NANCY BANG-CHUNG. WU (7978349)
core  

Friend, Not Foe: Lowered Tissue Reactivity to Long‐Term Polyimide Implants

Advanced Science, EarlyView.
The choice of optimal neural probe designs remains a major challenge in the field of neurotechnology. This study investigated the biocompatibility of several probe variations, including material, thickness, width, and implantation strategy. It highlights the clear advantage of soft polyimide probes over stiff silicon probes for better device ...
Corinne Orlemann, Laura M. De Santis, Paul Neering, Christian Boehler, Kirti Sharma, Arno Aarts, Tobias Holzhammer, Rik J. J. van Daal, Patrick Ruther, Maria Asplund, Roxana N. Kooijmans, Pieter R. Roelfsema   +11 more
wiley   +1 more source

Cannabis-associated hyperalgesia and reduced local anesthetic efficacy in oral surgery: A case report. [PDF]

Toxicol Rep
Hammoud S, Magno MHI, Akhikar J, Filho LCM.   +3 more
europepmc   +1 more source

SYNTHESES AND LOCAL ANESTHETIC ACTIVITY OF SUBSTITUTED BENZOATES OF ORTHO-(HYDROXYMETHYL)-2-PHENETHYLAMINES.

, 1973
SYNTHESES AND LOCAL ANESTHETIC ACTIVITY OF SUBSTITUTED BENZOATES OF ORTHO-(HYDROXYMETHYL)-2 ...
JAUE-HUEY SHUE. HSIAO (7975784)
core