Results 291 to 300 of about 4,859,005 (380)

Targeting GPX4 to Induce Ferroptosis Overcomes Chemoresistance Mediated by the PAX8‐AS1/GPX4 Axis in Intrahepatic Cholangiocarcinoma

Advanced Science, EarlyView.
PAX8‐AS1 drives chemoresistance in intrahepatic cholangiocarcinoma by activating NRF2‐mediated GPX4 transcription and stabilizing GPX4 mRNA via IGF2BP3. Targeting the PAX8‐AS1/GPX4 axis with a GPX4 inhibitor enhances the efficacy of gemcitabine and cisplatin in preclinical models, offering a promising strategy to overcome chemotherapy resistance in ...
Zhi‐Wen Chen, Ji‐Jun Shan, Mo Chen, Zong Wu, Yi‐Ming Zhao, Hong‐Xu Zhu, Xin Jin, Yi‐Xiu Wang, Yi‐Bin Wu, Zhen Xiang, Zhi‐Wen Ding, Zhen‐Hai Lin, Long‐Rong Wang, Lu Wang   +13 more
wiley   +1 more source

Potential role of electroencephalographic monitoring for diagnosis and treatment of local anesthetic systemic toxicity during general anesthesia: a case report. [PDF]

JA Clin Rep
Wakabayashi R, Azuma S, Hayashi S, Ueda Y, Iwakiri M, Asamoto M, Uchida K.   +6 more
europepmc   +1 more source

Microanalysis of Local Anesthetics (II) : Qualitative Analysis by Thin-layer and Pre-treated Paper Chromatography

, 1966
Keiko Tanzawa, Otomatsu Hoshino, Tyunosin Ukita   +2 more
openalex   +2 more sources

Dual‐Biomimetic Bone Adhesive with Osteoimmunomodulatory Capabilities for Anatomical Reconstruction of Comminuted Fractures

Advanced Science, EarlyView.
A structurally and functionally dual bionic bone adhesive is engineered through an organic–inorganic cohesion strategy, which significantly reinforces the adhesive's bone tissue adhesion as well as osteogenic activity. In a pioneering rabbit radius comminuted fracture model, the bone adhesive exhibits exceptional capability in immobilizing bone ...
Junyao Cheng, Hufei Wang, Ming Li, Jianpeng Gao, Xiao Liu, Chuyue Zhang, Pengfei Chi, Bo Li, Yuan Xve, Daoyang Fan, Zheng Wang, Jianheng Liu, Xing Wang, Licheng Zhang   +13 more
wiley   +1 more source

Comparison of 2 Types of Local Anesthetic Techniques in the Reduction of Distal Radius Fracture: A Prospective Cohort Study. [PDF]

Hand (N Y)
Cela-López M, Domínguez-Prado DM, García-Reza A, Álvarez-Álvarez L, Pérez-Alfonso E, Oiartzabal-Alberdi I, Castro-Menéndez M.   +6 more
europepmc   +1 more source

EXPERIMENTAL ANALYSIS OF SHOCK CAUSED BY LOCAL ANESTHETIC AGENTS

, 1967
EITARO OGAWA
openalex   +2 more sources

Single‐Cell RNA Sequencing Delineates Renal Anti‐Fibrotic Mechanisms Mediated by TRPC6 Inhibition

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals how TRPC6 inhibition alters renal cell composition and gene expression in CKD. The study uncovers a novel endothelial subpopulation (ECRIN), highlights key inflammatory and fibrotic pathways, and identifies a Prnp‐driven network linked to fibrosis resolution, offering mechanistic insight into TRPC6 as a potential ...
Yao Xu, Zhihuang Zheng, Marleen Silke Oswald, Guozhe Cheng, Jun Liu, Qidi Zhai, Ute Kruegel, Michael Schaefer, Holger Gerhardt, Nicole Endlich, Maik Gollasch, Stefan Simm, Dmitry Tsvetkov   +12 more
wiley   +1 more source

Emerging Longer-Acting Local Anesthetic Formulations for Plastic Surgeons. [PDF]

Aesthet Surg J
Abi-Rafeh J, Covone J, Mroueh J, Henry N, Vorstenbosch J.   +4 more
europepmc   +1 more source

Effects of Some Counter Ions on Physico-chemical Properties and the Local Anesthetic Action of Dibucaine Base. II. : A New Method for Evaluating Local Anesthetic Action, determined on Frog's Sciatic Nerve Fibers

, 1966
Masaru Aoki, Noboru Yata
openalex   +2 more sources

METTL3/ALKBH5‐Mediated N6‐Methyladenosine Modification Drives Macrophage M1 Polarization via the SLC15A3‐TASL‐IRF5 Signaling Axis in Psoriasis

Advanced Science, EarlyView.
m6A modification stabilizes Slc15a3 mRNA in macrophages, activating the SLC15A3‐TASL‐IRF5 axis and promoting psoriatic inflammation. Abstract Impaired N6‐methyladenosine (m6A) modification has been implicated in regulating various inflammatory diseases, but its role in psoriasis remains unclear.
Tao Huang, Shijun Chen, Ke Ding, Liyan Yuan, Weiqi Lv, Kechen Chen, Yuchen Liu, Dongzhao Ma, Xin Zhang, Xiaobo Wang, Guanzheng Luo, Bin Yang, Ying Lin, Zhili Rong   +13 more
wiley   +1 more source