Results 291 to 300 of about 4,888,294 (346)

The efficacy of wound catheter infusion with local anesthetics for the treatment of postoperative pain in children: A systematic review. [PDF]

Paediatr Neonatal Pain
Swenker DJ, Dirckx M, Staals LM.
europepmc   +1 more source

Calhm6 Governs Macrophage Polarization Through Chp1‐Camk4‐Creb1 Axis and Ectosomal Delivery in Inflammatory Responses

Advanced Science, EarlyView.
Calhm6 drives M2 macrophage polarization via the Chp1‐Camk4‐Creb1 axis, suppressing inflammation through calcium‐dependent ectosomal delivery. Calhm6 deficiency enhances M1 responses, boosting bactericidal activity but exacerbating tissue damage. LPS/IFNγ upregulate Calhm6 via Irf1, while IL‐4/Stat6 inhibits it, balancing immune outcomes.
Yanlong Xin, Xiaofan Xiong, Yan Zhang, Siyu Zhang, Shuting Zhang, Yu Yang, Yingxue Liang, Lulu Zang, Xi Chen, Wenjuan Li, Issam Halalmeh, Rui Zhou, Zongfang Li, Haowen Liu, Jing Geng   +14 more
wiley   +1 more source

Replacing BPA: Structural Substitutes BPAF Binding to the Progesterone Receptor Elevates Breast Cancer Risk

Advanced Science, EarlyView.
This study demonstrates that bisphenol analogues, particularly BPAF, bind to progesterone receptor, promoting breast cancer cell proliferation, migration, and mammary tumor growth, indicating that bisphenol A substitutes may pose equal or greater health risks.
Xiaotong Ji, Peilin Li, Haoyang Wu, Linzhuo Shen, Xiaoyun Wu, Peiyun Jiang, Yating Li, Xiaozheng Zhang, Huifeng Yue   +8 more
wiley   +1 more source

Assessment of Cranial Spread of Two Different Volumes of Local Anesthetics Using Ultrasound during Caudal Blockade in Children.

Ann Afr Med
Thaleppady M, John N, Kulkarni M, Rani KR, Satish A, Shenoy L.   +5 more
europepmc   +1 more source

NNMT Orchestrates Metabolic‐Epigenetic Reprogramming to Drive Macrophage‐Myofibroblast Transition in Hypertrophic Scarring

Advanced Science, EarlyView.
In macrophage‐myofibroblast transition, upregulated NNMT depletes S‐Adenosylmethionine‌ (SAM) and nicotinamide adenine dinucleotide(NAD+), thereby triggering epigenetic reprogramming via Histone H3 Lysine 27 acetylation (H3K27ac) accumulation at the promoter region of master transcription factor Prrx1.
Xiwen Dong, Weinan Guo, Yuxuan Qian, Wenyan Jin, Xiaozhen Li, Jingyuan Yang, Qingrong Ni, Shuang Wu, Fanni Li, Hua Wang, Chunying Li, Hong Cai   +11 more
wiley   +1 more source

Pharmacological Microglial Inhibition Remodels the Scar Microenvironment to Support Reticulospinal Circuit Reconstruction After Spinal Cord Injury

Advanced Science, EarlyView.
This study establishes pharmacological microglial inhibition as a therapeutic strategy, demonstrating its capacity to remodel the lesion microenvironment through significant reduction of extracellular matrix deposition. This permissive environmental transformation facilitates robust regeneration of the reticulospinal tract, and reconstructs functional ...
Run Li, Hongyuan Xing, Yifan Shen, Meng Chen, Bowen Lyu, Xiaofeng Yang, Li Sun, Chao Jiang, Jianyu Lv, Xin Ding, Zhongyang Gao, Yue Wang   +11 more
wiley   +1 more source

Lipophilicity of drugs, including local anesthetics, and its association with lipid emulsion resuscitation. [PDF]

Korean J Anesthesiol
Wiedmer SK, Sohn JT.
europepmc   +1 more source

AI‐Assisted Detection of Early Gastric Cancer via Visualization of Mucosal Acidity Compromise During Endoscopy

Advanced Science, EarlyView.
An AI‐assisted SERS system is developed to rapidly and reliably detect early gastric cancer by visualizing gastric mucosal acidity, enhancing endoscopic differentiation, improving guidance for submucosal dissection, and reducing false‐positive diagnoses.
Huihui Yan, Zongkuo Li, Jing Zhao, Lei Su, Ziyi Jin, Weiyi Zhao, Rong Duan, Suhongrui Zhou, Lingling Wang, Jianshan Mao, Xinliang Lu, Weihao Gai, Yang Du, Qin Du, Cheng Fang, Yiming Zhao, Yan You, Jianting Cai, Cong Li   +18 more
wiley   +1 more source

Impact of gadolinium-based MRI contrast agent and local anesthetics co-administration on chondrogenic gadolinium uptake and cytotoxicity. [PDF]

Heliyon
Zimmerer A, Schulze F, Gebhardt S, Huesker K, Stobbe D, Grolimund D, Hesse B, Wassilew GI, Schoon J.   +8 more
europepmc   +1 more source