Results 81 to 90 of about 86,511 (347)

Advances of Nano-Structured Extended-Release Local Anesthetics

Nanoscale Research Letters, 2020
Extended-release local anesthetics (LAs) have drawn increasing attention with their promising role in improving analgesia and reducing adverse events of LAs.
Yumiao He, Linan Qin, Yuguang Huang, Chao Ma   +3 more
doaj   +1 more source

Synergistic Osteogenesis After Co‐Administration of cmRNAs Encoding BMP‐2 and BMP‐7 Utilizing a Transcript‐Activated Matrix

Advanced Functional Materials, EarlyView.
This study demonstrates that the dual delivery of BMP‐2/‐7 coding cmRNAs for bone healing is demonstrated as feasible, safe, and highly osteogenic. Compared to single BMP‐2 or BMP‐7 cmRNAs, the combination enhances the production of both mineral and organic components of the extracellular matrix when delivered using a collagen‐HA scaffold, supporting ...
Claudia Del Toro Runzer, Joanna M. Sadowska, Nadia Roumans, Christian Plank, Christopher H. Evans, Fergal J. O'Brien, Martijn van Griensven, Elizabeth R. Balmayor   +7 more
wiley   +1 more source

Disputed issues of systemic toxicity of local anesthetics

Вестник анестезиологии и реаниматологии, 2020
Objective: assessment of the "systemic toxicity of local anesthetics,” term validity, and a legal appraisal of the term “lipid resuscitation.” Regulatory documents and specialized literature devoted to the terminology of toxicity of local anesthetics ...
V. V. Unzhakov, E. S. Netesin, V. I. Gorbachev   +2 more
doaj   +1 more source

Mechanically Tunable Bone Scaffolds: In Vivo Hardening of 3D‐Printed Calcium Phosphate/Polycaprolactone Inks

Advanced Functional Materials, EarlyView.
A 3D bone scaffold with osteogenic properties and capable of hardening in vivo is developed. The scaffold is implanted in a ductile state, and a phase transformation of the ceramic induces the stiffening and strengthening of the scaffold in vivo. Abstract Calcium phosphate 3D printing has revolutionized customized bone grafting.
Miguel Mateu‐Sanz, Pablo Varela, Laura del‐Mazo‐Barbara, Irene Lodoso‐Torrecilla, Emilio Jiménez‐Piqué, Jordi Franch, Miguel Alaminos, Maria‐Pau Ginebra   +7 more
wiley   +1 more source

Comparative effectiveness of nerve block strategies for preventing postherpetic neuralgia in thoracic herpes zoster: a network meta-analysis

Frontiers in Neurology
BackgroundShingles is a common global disease, with the chest region being one of its most frequently affected areas. Postherpetic neuralgia (PHN) is one of the most common and debilitating complications of this disease, characterized by high incidence ...
Wensheng Lu, Shengze He, Qi Liu, Yaozu Gu, Jie Bai   +4 more
doaj   +1 more source

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

Advanced Functional Materials, EarlyView.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen, Sabah Kasmi, Shrinivas Dumbre, Lies Baekens, Elise Seynaeve, Louise Van den Hauwe, Niccolò Cantini, Aello Garantoudi, Filipe Branco Madeira, Alain Marrot, Emma Tuypens, Sofie Seghers, Anna Kuchmiy, Elisabeth Brabants, Bart Vanderborght, Ine Maes, Sarah Vandenberghe, Jessica Filtjens, Alícia Gordún Peiró, Daliya Kancheva, Ayla Debraekeleer, Florence Lambolez, Emily De Lombaerde, Yong Chen, Rafael Miyazawa Martins, Pauline Formaglio, Damya Laoui, Sofie Deschoemaeker, Bruno G. De Geest, Rogerio Amino, Stefaan De Koker   +30 more
wiley   +1 more source

Systemic toxisity of local anesthethics during regional anesthesia in orthopedics and traumatology

Travmatologiâ i Ortopediâ Rossii, 2016
There are cases of accidental intravascular injection of local anesthetic when performing regional anesthesia. The frequency of this complication was 0.28 per 1,000.
V. A. Koryachkin, V. G. Chupris, A. Z. Cherny, V. S. Kasarin, M. A. Lis’Kov, G. M. Malevich, M. P. Maltsev   +6 more
doaj  

Bupivacaína racêmica a 0,5% e mistura com excesso enantiomérico de 50% (S75-R25) a 0,5% no bloqueio do plexo braquial para cirurgia ortopédica. Estudo comparativo Bupivacaína racémica a 0,5% y mezcla con exceso enantiomérico del 50% (S75-R25) a 0,5% en el bloqueo del plexo braquial para cirugía ortopédica. Estudio comparativo Comparative study of 0.5% racemic bupivacaine versus enantiomeric mixture (S75-R25) of 0.5% bupivacaine in brachial plexus block for orthopedic surgery

Revista Brasileira de Anestesiologia, 2005
JUSTIFICATIVA E OBJETIVOS: Com a finalidade de encontrar uma droga mais segura que a bupivacaína racêmica, vários estudos foram realizados com seus isômeros.
Roberto Tsuneo Cervato Sato, Douglas Flávio Porsani, Antônio Garibaldino Vieira do Amaral, Oscar Vilmar Schulz Júnior, Ângelo Manoel Grande Carstens   +4 more
doaj   +1 more source

Local anesthetics induce autophagy in young permanent tooth pulp cells [PDF]

, 2015
Pulp cells are essential for tooth development, and dentin repair and regeneration. In addition these cells have been identified as an important stem cell source.
Ali, K, Ardu, S, Hu, B, Hu, D, Luo, S, Nisr, RB, Singer, D, Tieu, K, Tredwin, C, Walker, JV, Zhuang, H   +10 more
core   +3 more sources