Results 81 to 90 of about 47,127 (296)

Current Concepts of the Mechanism of Action of Local Anesthetics

, 1981
Recent experiments are reviewed to present a current view of the mechanisms of conduction block by local anesthetics. Local anesthetics block the sodium channels whose opening causes the rising phase of the action potential.
Gary R. Strichartz
core   +1 more source

Associations of Rheumatoid Arthritis Disease Activity With Frailty Over Five Years of Follow‐up

Arthritis Care &Research, EarlyView.
Objective To evaluate whether rheumatoid arthritis (RA) disease activity is associated with frailty both in cross‐section and longitudinally. Methods Participants within the Veterans Affairs Rheumatoid Arthritis (VARA) registry enrolled from 2003 to 2022 were included.
Courtney N. Loecker, Yangyuna Yang, Punyasha Roul, Aaron Baraff, Myra S. Schmaderer, Lani Zimmerman, Kaleb Michaud, Namrata Singh, Grant W. Cannon, Gary Kunkel, Ted R. Mikuls, Ariela R. Orkaby, Joshua F. Baker, Bryant R. England, Katherine D. Wysham   +14 more
wiley   +1 more source

Systemic toxisity of local anesthethics during regional anesthesia in orthopedics and traumatology

Travmatologiâ i Ortopediâ Rossii, 2016
There are cases of accidental intravascular injection of local anesthetic when performing regional anesthesia. The frequency of this complication was 0.28 per 1,000.
V. A. Koryachkin, V. G. Chupris, A. Z. Cherny, V. S. Kasarin, M. A. Lis’Kov, G. M. Malevich, M. P. Maltsev   +6 more
doaj  

Inhibitory effects of local anesthetics on the proteasome and their biological actions [PDF]

Local anesthetics (LAs) inhibit endoplasmic reticulum-associated protein degradation, however the mechanisms remain elusive. Here, we show that the clinically used LAs pilsicainide and lidocaine bind directly to the 20S proteasome and inhibit its ...
ヒサトメ, イチロウ, 河田, 康志, イトウ, トシユキ, イノウエ, マサシ, 山口, 博司, Bahrudin, Udin, Obara, Yuji, ニノミヤ, ハルアキ, 1457, Yamaguchi, Hiroshi, 李, 佩俐, バフルディン, ウディン, ヤマグチ, ヒロシ, Saeki, Yasushi, 40464292, 加藤, 克, リ, ペイリ, Kita, Akiko, Tsujitani, Shunichi, Inoue, Masashi, 27414, Ninomiya, Haruaki, 27415, 27418, 27419, 27416, 27417, Li, Peili, 3805, 30304207, 765, 100000877, Kato, Masaru, ツジタニ, シュンイチ, 二宮, 治明, Hisatome, Ichiro, 27425, 井上, 雅史, 27426, 27423, 27424, 27429, 100000183, Morimoto, Yukio, 27427, 27428, 40467709, 27421, 27422, Sakane, Isao, 27420, 100000348, 伊藤, 敏幸, 2609, Nishio, Kazuya, 100000307, 1879, Itoh, Toshiyuki, Murakami, Takuto, Unno, Masaki, 60211504, Kawata, Yasushi, Sugiyama, Rina, カトウ, マサル, カワタ, ヤスシ, 80212124, 100000496, 1367, 100000212, Tanaka, Keiji, 27430, 久留, 一郎, 27431, 40177697   +73 more
core   +1 more source

Cracking the Code: Which Ocular Symptoms Predict Dry Eye Signs? Insights From a Large International Sicca Registry

Arthritis Care &Research, EarlyView.
Objective The study aimed to identify symptom‐based predictors of dry eye disease (DED) signs in the Sjögren's International Collaborative Clinical Alliance (SICCA) cohort. Methods We performed a retrospective analysis examining 16 ocular symptoms (most graded 0–4) and artificial tear (AT) use (graded 0–3) as predictors of DED signs (abnormal ocular ...
Pragnya R. Donthineni, Chloe Shields, Rohit Muralidhar, Shreya Bhatt, Alan Baer, Robert Fox, Sara S. McCoy, Anat Galor   +7 more
wiley   +1 more source

Physician‐Scientist Pipeline for Pediatric Rheumatology: The Current Landscape and Future Perspectives

Arthritis Care &Research, EarlyView.
Over the past 50 years, the science of pediatric rheumatology has grown exponentially due to an expansion in the understanding of complex rheumatic conditions and a surge in novel targeted therapeutics. Physician‐scientists in the field of pediatric rheumatology have played major roles in these advancements that have improved the care of children ...
Ekemini A. Ogbu, Linda T. Hiraki, Mara L. Becker   +2 more
wiley   +1 more source

Direct Inhibition of Microtubule-Based Kinesin Motility by Local Anesthetics

, 2000
Local anesthetics are known to inhibit neuronal fast anterograde axoplasmic transport (FAAT) in a reversible and dose-dependent manner, but the precise mechanism has not been determined.
Yanagida, Toshio, Miyamoto, Yoshikazu, Muto, Etsuko, Mashimo, Takashi, Yoshiya, Ikuto, Iwane, Atsuko H.   +5 more
core   +1 more source

Distinct Systemic Sclerosis Phenotypes Related to Ethnicity: An Opportunity to Personalize Care?

Arthritis Care &Research, EarlyView.
Objective The objective is to describe and compare demographic, clinical, and serological characteristics of patients with systemic sclerosis (SSc) according to ethnic background. Methods Participants enrolled in the Canadian Scleroderma Research Group cohort who self‐identified to a single ethnicity group were included.
Danick Goulet, Camille Guertin, Maggie Larché, Isabelle Ferdinand, Marie Hudson, May Y. Choi, Mohammed Osman, Janet Pope, Carter Thorne, Murray Baron, Sasha Bernatsky, Sabrina Hoa   +11 more
wiley   +1 more source

Efficacy of low-dose hypobaric anesthetics in spinal anesthesia for cesarean delivery: systematic review and meta-analysis

The Journal of Maternal-Fetal & Neonatal Medicine
Objective Many studies have compared the anesthetic effects of different doses of hypobaric local anesthetics (without glucose) in spinal anesthesia for cesarean sections.
Min Li, Guohao Xie, Lihua Chu, Yan Li
doaj   +1 more source

Bloqueio do plexo braquial por via supraclavicular: estudo clínico comparativo entre bupivacaína e levobupivacaína Bloqueo del plexo braquial por vía supraclavicular: estudio clínico comparativo entre bupivacaína y levobupivacaína Supraclavicular brachial plexus block: a comparative clinical study between bupivacaine and levobupivacaine

Revista Brasileira de Anestesiologia, 2009
JUSTIFICATIVA E OBJETIVOS: O bloqueio de plexo braquial é técnica anestésica utilizada para procedimentos em membros superiores. O plexo braquial é território potencial para absorção de anestésicos locais.
José Ricardo Pinotti Pedro, Lígia Andrade Silva Telles Mathias, Judymara Lauzi Gozzani, Flavia Salles de Souza Pinotti Pedro, José Carlos Rittes   +4 more
doaj   +1 more source