Results 111 to 120 of about 443,473 (282)

Features of the Formation of City Government Bodies in Tomsk Governorate under the Reform of 1892

open access: yesHistoria provinciae: журнал региональной истории
The article investigates the key features of the formation of local self-government bodies (city councils, meetings of city commissioners, and city administrations) in Tomsk Governorate following the reform of 1892.
Aleksandr B. Khramtsov
doaj   +1 more source

Children Act 1989 Guidance and Regulations. Volume 5: Children's Homes [PDF]

open access: yes, 2011
"Volume 5 of the Children Act Regulations and Guidance provides guidance to local authorities in England and their staff, about their functions under Parts 3 and 6-8 of the Children Act 1989." - Page ...

core  

Evidence of Iron Accumulation in Cerebral Adrenoleukodystrophy: A Potential Novel Disease Mechanism

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT In this first application of Quantitative Susceptibility Mapping Source Separation to cerebral adrenoleukodystrophy, we uncovered alterations in iron and myelin within lesions and normal appearing white matter. As validation, we demonstrate abnormal iron accumulation in those same compartments within primary brain tissue.
Christina L. Nemeth   +8 more
wiley   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang   +8 more
wiley   +1 more source

The Influence of Revenue Sources on the Financial Independence and Investment Activity of Communes and Cities with 'Powiat' Rights in Poland

open access: yesPrace Naukowe Uniwersytetu Ekonomicznego we Wrocławiu, 2019
Local government is a part of the public finance sector, therefore a significant part of its income has a strictly defined purpose. Such focusing of income on the financing of specific tasks limits the scope of the financial autonomy of local government ...
Krzysztof Surówka
doaj  

Sex Representation in US Stroke Clinical Trials: A Decade of Trends and Challenges

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stroke remains a major cause of disability and mortality in the US, with significant sex‐based disparities, and females remain underrepresented in stroke clinical trials. We aimed to examine sex representation in US‐based stroke clinical trials, identify trial characteristics associated with higher female enrollment (≥ 50%), and ...
Chaitali Dagli   +5 more
wiley   +1 more source

The death of reflective supervision? An exploration of the role of reflection within\ud supervision in a Local Authority Youth Offending Service

open access: yes, 2014
Reflection within supervision has been identified as key to effective social work practice\ud (Munro, 2011). However, despite the tradition of supervision being strongly embedded in youth\ud justice practice, other imperatives, such as audit monitoring and the focus on inspection\ud readiness, have impacted on the content of supervision and the degree ...
openaire  

Cracking the Code: Genotype–Phenotype Correlation Models in Sarcoglycanopathies

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Sarcoglycanopathies are among the most severe limb‐girdle muscular dystrophies (LGMD), though milder presentations have been described. These diseases are primarily caused by missense variants, but the limited predictability of their effect on protein maturation, complex formation, and transport has hindered reliable genotype ...
Leonela Luce   +72 more
wiley   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling   +16 more
wiley   +1 more source

IV Thrombolysis Facilitates Interventional Reperfusion in Non‐Cardioembolic but Not Cardioembolic Stroke

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intravenous thrombolysis (IVT) before thrombectomy for ischemic stroke may alter clot structure and procedural performance. We investigated how IVT relates to thrombectomy metrics across stroke etiologies. Methods We performed a time‐to‐event analysis of consecutive patients with anterior circulation large vessel occlusion (acLVO ...
Annahita Sedghi   +8 more
wiley   +1 more source

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