Results 41 to 50 of about 443,473 (282)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Survey on and Countermeasures for Chemical Pollution of Water Used in Large Hotels: a Case Study
Chemical Engineering Transactions, 2017 Water for hotel use mainly includes air conditioning circulating water and shower water. This paper conducts a survey on the current status of chemically polluted water in hotels in some area and analyses relevant countermeasures, hoping to give an ...
Shiying Yang, Hongfang Tian, Jingna Shi
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Кавказология, 2023 The subject of trust in public-state interactions and local self-government is examined using the example of agrarian protests on Zolsky pastures grasslands in Nalchik district in June 1913.
Dmitry Nikolaevich Prasolov
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Transparency of the budget process as a prerequisite for financial decentralization in Ukraine [PDF]
Public and Municipal Finance, 2018 The introduction of a qualitatively new type of relationship between citizens and authorities, one in which every person would be guaranteed real observation and protection of the rights and freedoms in these bodies activity, should be one of the ...
Inna Shkolnyk +2 more
doaj +1 more source
Imperial subventions towards services administered by local authorities in England and Wales [PDF]
, 1925 In the realm of Local Government there is probably no question of such importance or of so controversial a nature as that of the relationship which should exist between the central Government and the Local Authorities whose actions it at present so ...
Holden, Charles Garrett
core
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
The development and year one implementation of the Local Justice Reinvestment Pilot [PDF]
, 2013 This report focuses on the initial findings from a process evaluation of the Local Justice Reinvestment pilot (commissioned by the Ministry of Justice), which examines the early development and implementation of the pilot in the first test year.
Barraclough, Nicola +5 more
core
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source