Results 41 to 50 of about 445,597 (304)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Using participatory action research to empower district hospital staff to deliver quality-assured essential surgery to rural populations in Malawi, Zambia, and Tanzania

open access: yesFrontiers in Public Health, 2023
BackgroundIn 2017 the SURG-Africa project set out to institute a surgical, obstetric, trauma and anesthesia (SOTA) care capacity-building intervention focused on non-specialist providers at district hospitals in Zambia, Malawi and Tanzania.
Chiara Pittalis   +11 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Survey on and Countermeasures for Chemical Pollution of Water Used in Large Hotels: a Case Study

open access: yesChemical Engineering Transactions, 2017
Water for hotel use mainly includes air conditioning circulating water and shower water. This paper conducts a survey on the current status of chemically polluted water in hotels in some area and analyses relevant countermeasures, hoping to give an ...
Shiying Yang, Hongfang Tian, Jingna Shi
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Zolsky uprise 1913 as a crisisis of trust in practices of society-state interaction in Nalchik district

open access: yesКавказология, 2023
The subject of trust in public-state interactions and local self-government is examined using the example of agrarian protests on Zolsky pastures grasslands in Nalchik district in June 1913.
Dmitry Nikolaevich Prasolov
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Transparency of the budget process as a prerequisite for financial decentralization in Ukraine [PDF]

open access: yesPublic and Municipal Finance, 2018
The introduction of a qualitatively new type of relationship between citizens and authorities, one in which every person would be guaranteed real observation and protection of the rights and freedoms in these bodies activity, should be one of the ...
Inna Shkolnyk   +2 more
doaj   +1 more source

The emergence of labour camps in Shandong province, 1942-1950 [PDF]

open access: yes, 2003
This article analyses the emergence of labour camps in the CCP base area of Shandong province from 1942 to 1950. By using original archival material, it provides a detailed understanding of the concrete workings of the penal system in a specific region ...
Dikötter, Frank
core   +1 more source

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