Results 211 to 220 of about 10,137,913 (308)

Mesoscale Recovery of Microglial and Neuronal Dynamics After Craniotomy Across Wide Cortex in Transgenic Mice

Advanced Science, EarlyView.
This study employs longitudinal fluorescence imaging in transgenic mice to map post‐craniotomy cortical recovery. We identify distinct neuroimmune recovery phases: microglial structural inflammation peaks at ∼10 days, neuronal structural intensity peaks at ∼14 days and correlates with microglial activity, and functional network modularity is most ...
Guihua Xiao, Zhilei Wang, Pengchang Zheng, Jingyu Xie, Yangzhen Wang, Yun Chen, Zilin Wang, Ao Li, Minghuan Wang, Quanbo Ji, Can Gao, Di Yao, Lingbo Li, Jiangbei Cao   +13 more
wiley   +1 more source

Extracellular Vesicles of Streptococcus anginosus Mediate Gastritis via Epithelial Barrier Disruption and Macrophage‐driven Inflammation

Advanced Science, EarlyView.
Streptococcus anginosus extracellular vesicles (SA‐EVs) accumulate in gastric tissue, disrupt epithelial tight junctions, and induce gastritis characterized by neutrophil infiltration and elevated cytokines (TNF‐α, IL‐6, IL‐17A). Proteomics identifies TMPC and FBP62 as key SA‐EVs virulence factors; their genetic deletion attenuates inflammation ...
Ying Gong, Lina Duan, Jie Xiao, Yulu Deng, Hongxia Wang, Yajie Zhang, Xiumei Hu, Haifang Wang, Taixue An, Xin Li, Yurong Qiu, Lei Zheng, Haixia Li   +12 more
wiley   +1 more source

Local communication toolbox

SUNRISE will help residents, users, stakeholders, decision makers and private sector representatives in the six action neighbourhoods to analyse and articulate their own situation as an opportunity for reflection, learning and sharing. For this purpose, SUNRISE will provide tools to visualise the local challenges and options.
openaire   +1 more source

MGM as a Large‐Scale Pretrained Foundation Model for Microbiome Analyses in Diverse Contexts

Advanced Science, EarlyView.
We present the Microbial General Model (MGM), a transformer‐based foundation model pretrained on over 260,000 microbiome samples. MGM learns contextualized microbial representations via self‐supervised language modeling, enabling robust transfer learning, cross‐regional generalization, keystone taxa discovery, and prompt‐guided generation of realistic,
Haohong Zhang, Yuli Zhang, Zixin Kang, Jiayun Xiong, Ronghua Yang, Kang Ning   +5 more
wiley   +1 more source

Inulin‐Based Oral Chemotherapy Modulates Gut Microbiota and Immune Microenvironment through Inhibition of Neutrophil Extracellular Trap Formation for Improving Cancer Therapy

Advanced Science, EarlyView.
Schematic representation of ZIF‐8@OXA@inulin for cancer immunotherapy. Synthesis of ZIF‐8@OXA@inulin. Augmentation of pyroptosis, regulation of gut microbiota, and inhibition of NETs formation by ZIF‐8@OXA@inulin‐mediated comprehensive strategy for antitumor immune response. ABSTRACT Despite the potential of chemoimmunotherapy against colorectal cancer
Zhenhao Li, Jiaqiang Jiang, Yuping Zhou, Xinyuan Mao, Haotian Wen, Zhian Chen, Yutong Wang, Cong Huang, Yanfeng Hu   +8 more
wiley   +1 more source

Co-resistance between oral antibiotics for pyelonephritis and those for simple urinary tract infections – Applying an Escalation Antibiogram Model to local community data

Williams P, Barton E, Bhamber R, Gorman L, Dowsey AW, Avison MB.   +5 more
europepmc   +1 more source

"We might not have been in hospital, but we were frontline workers in the community": a qualitative study exploring unmet need and local community-based responses for marginalised groups in Greater Manchester during the COVID-19 pandemic. [PDF]

BMC Health Serv Res
Gillibrand S, Watkinson R, Surgey M, Issa B, Sanders C.   +4 more
europepmc   +1 more source

Material‐Induced Nuclear Deformation Controls Chromatin Architecture in Adipose Stem Cells

Advanced Science, EarlyView.
Tuning cell and cytoskeleton mechanics modulated nuclear shape and heterochromatin organization in ASCs. Distinct cytoskeletal architectures induced nuclear morphologies from oblate to prolate ellipsoids. Large elongated cells with a structured actin cap exhibited high nuclear strain, driving nuclear envelope deformation and heterochromatin ...
Carlo F. Natale, Luca Messina, Valeria Panzetta, Stefania Saporito, Costantino Menna, Maurizio Ventre, Paolo A. Netti   +6 more
wiley   +1 more source

Correction: Increasing access to screening for blood-borne viruses and sexually transmissible infections for Aboriginal and Torres Strait Islander Australians: evaluation of the Deadly Liver Mob program’s ‘cascade of care’ across nine sites in New South Wales, Australia

Harm Reduction Journal
Elena Cama, Kim Beadman, Mitch Beadman, Kerri-Anne Smith, Jade Christian, Aunty Clair Jackson, Beverley Tyson, Clayton Anderson, Larissa Smyth, Jennifer Heslop, Gary Gahan, Victor Tawil, Felicity Sheaves, Louise Maher, Julie Page, Donna Tilley, Ann Ryan, Kim Grant, Basil Donovan, Annabelle Stevens, Trevor Slattery, Kate Pearce, Franklin John-Leader, Andrew Walden, Jo Lenton, Margaret Crowley, Carla Treloar   +26 more
doaj   +1 more source

Local communication strategy

The local dissemination plan will define the activities to be carried out at a local level focus, the primary target group would be citizens, industry and regionally close cities. The strategy will outline the main activities which will be completed by the Lighthouse Cities in the scope of the project including: digital media, the materials to be ...
openaire   +1 more source