Results 41 to 50 of about 995,713 (260)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Using the ‘F-words’ to adopt a holistic and child rights promoting approach in developmental assessment clinics in Sydney: a quality improvement study

BMJ Paediatrics Open
Background The way childhood disability is understood and represented in various domains is evolving. The ‘F-words for Child Development’, derived from The International Classification of Functioning, Disability and Health, is a framework that is gaining
Sinthu Vivekanandarajah, Lydia So, Zien Vanessa Tan, Jenna Ohlsen, Bronya Cruickshank   +4 more
doaj   +1 more source

The effects of an innovative GP-physiotherapist partnership in improving COPD management in primary care

BMC Primary Care, 2023
Background Evidence suggests that management of people with Chronic Obstructive Pulmonary Disease (COPD) in primary care has been suboptimal, in particular, with low referral rates to pulmonary rehabilitation (PR).
Lisa Pagano, Sarah Dennis, Sally Wootton, Andrew S. L. Chan, Nicholas Zwar, Sriram Mahadev, Deborah Pallavicini, Zoe McKeough   +7 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

BOOK REVIEW: DIY Community Action: Neighbourhood problems and community self-help (by Liz Richardson)

Commonwealth Journal of Local Governance, 2009
This book explores collaborative community engagement for local well-being initiatives, and is substantially based on the experiences and perspectives of activist groups in low-income neighbourhoods across the United Kingdom.
Jenny Wills
doaj   +1 more source

Process Algebra with Local Communication

Electronic Notes in Theoretical Computer Science, 2008
AbstractIn process algebras like μCRL and ACP communication is defined globally. In the context of component-based architectures one wishes to define subcomponents of a system separately, including communication within that subcomponent. We define a process algebra with an operator for local communication that facilitates component-based architectures.
openaire   +3 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Moving from idea to reality: The barriers and enablers to implementing Child and Family Hubs policy into practice in NSW, Australia

Health Research Policy and Systems
Background Adverse childhood experiences can impact physical and mental health throughout the lifespan. To support families experiencing adversity and improve child health and developmental equity, an integrated, multi-sector response is required.
Anna Calik, Huei Ming Liu, Alicia Montgomery, Suzy Honisett, Kerri-Anne Van Munster, Tamara Morris, Valsamma Eapen, Sharon Goldfeld, Harriet Hiscock, John Eastwood, Susan Woolfenden   +10 more
doaj   +1 more source

Validation of the 24-item recovery assessment scale-revised (RAS-R) in the Norwegian language and context: a multi-centre study

Health and Quality of Life Outcomes, 2018
Background The Recovery Assessment Scale-revised (RAS-R) is a self-report instrument measuring mental health recovery. The purpose of the present study was to translate and adapt the RAS-R into the Norwegian language and to investigate its psychometric ...
Eva Biringer, Marit Tjoflåt
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source