Results 41 to 50 of about 952,672 (262)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Local Community

INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT
I.     ABSTRACT Local Community is a mobile application created to help in a local area share information and support each other. Sometimes people need quick help, such as blood donation, finding lost items, or getting information about nearby services. In many cases, it is difficult to inform others in the community quickly.
Ms. Bhandare Harshda Sunil, Vardhave Ruchita Prashant, Ms. Rodage Srushti Shrishail, Ms, Dhulam Rekha Pandharinath, Ms. Bhinge Sanjana Mallikarjun, Ms. Kalshetti Priti Dayanand, Ms. Durshetti Rachana Ravindra   +6 more
openaire   +2 more sources

The safety of health care for ethnic minority patients: a systematic review

International Journal for Equity in Health, 2020
Introduction Evidence to date indicates that patients from ethnic minority backgrounds may experience disparity in the quality and safety of health care they receive due to a range of socio-cultural factors.
Ashfaq Chauhan, Merrilyn Walton, Elizabeth Manias, Ramesh Lahiru Walpola, Holly Seale, Monika Latanik, Desiree Leone, Stephen Mears, Reema Harrison   +8 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Caregiver experiences of accessing a child developmental assessment service in a culturally diverse population in Australia: a mixed methods study

BMJ Paediatrics Open
Background While there is a high level of concern among parents about waiting for child developmental services, there is limited research on caregiver perspectives on accessing public developmental diagnostic services, especially for families from ...
Shanti Raman, Romy Hurwitz, Yvonne Teoh, Nugroho Karyadiguna, Sinthu Vivekanandarajah, Lydia So   +5 more
doaj   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

The co-development of a linguistic and culturally tailored tele-retinopathy screening intervention for immigrants living with diabetes from China and African-Caribbean countries in Ottawa, Canada

BMC Health Services Research, 2023
Background Diabetic retinopathy is a sight-threatening ocular complication of diabetes. Screening is an effective way to reduce severe complications, but screening attendance rates are often low, particularly for newcomers and immigrants to Canada and ...
Valerie Umaefulam, Mackenzie Wilson, Marie Carole Boucher, Michael H. Brent, Maman Joyce Dogba, Olivia Drescher, Jeremy M. Grimshaw, Noah M. Ivers, John G. Lawrenson, Fabiana Lorencatto, David Maberley, Nicola McCleary, Sheena McHugh, Olivera Sutakovic, Kednapa Thavorn, Holly O. Witteman, Catherine Yu, Hao Cheng, Wei Han, Yu Hong, Balkissa Idrissa, Tina Leech, Joffré Malette, Isabelle Mongeon, Zawadi Mugisho, Marlyse Mbakop Nguebou, Sara Pabla, Siffan Rahman, Azaratou Samandoulougou, Hasina Visram, Richard You, Junqiang Zhao, Justin Presseau   +32 more
doaj   +1 more source

Intelligent Tutoring Systems for Adult Learning in STEM Disciplines

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley   +1 more source