Results 11 to 20 of about 1,311,159 (211)
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Global Culture, Local Cultures, and the Internet. The Thai Example [PDF]
, 1998 This paper addresses the questions of whether, and if so, how and to what extent the Internet brings about homogenization of the local cultures in the world. It examines a particular case, that of Thai culture, through an investigation and interpretation
Hongladarom, Soraj
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JUXTAPOSING L 1 CULTURE AND L 2 CULTURE IN ELT MATERIALS [PDF]
, 2016 It is generally agreed that learning language means learning culture since language is a part of culture. In English Language Teaching (ELT) context, the process of teaching and learning will basically involve two cultures: L1 culture referring to ...
Suharno , Suharno
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Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Social deprivation and widening participation: the continuing power of local cultures [PDF]
, 2010 This paper considers social deprivation and widening participation in a South Yorkshire community. It examines why young adults living within a working class community choose not to enter higher education. It discusses the expectations, motivations and
Bailey, Wayne
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Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
MAINTAINING VERNACULARS TO PROMOTE PEACE AND TOLERANCEIN MULTILINGUAL COMMUNITY IN INDONESIA [PDF]
, 2011 Indonesia is a large nation in terms of ethnics, cultures, and vernaculars. Indonesian constitution guarantees that the cultures, vernaculars will be taken care of by the government.
,, Rustipai , Katharina
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