Results 31 to 40 of about 1,311,159 (211)

East–West Perspectives on Privacy, Ethical Pluralism and Global Information Ethics [PDF]

open access: yes, 2008
Information and Communication Technologies (ICTs) are both primary drivers and facilitating technologies of globalization—and thereby, of exponentially expanding possibilities of cross-cultural encounters.
Ess, Charles
core  

Digital libraries and minority languages [PDF]

open access: yes, 2005
Digital libraries have a pivotal role to play in the preservation and maintenance of international cultures in general and minority languages in particular.
Bainbridge, David   +4 more
core   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Sickness Absence and Local Cultures [PDF]

open access: yesPublikationer från Örebro universitet, 2010
Sickness absence has been found to vary substantially across geographical areas. There are large differences between different countries but also between different regions within a particular country. In the literature some of these observed differentials have been suggested to stem from differences in local norms with regard to the legitimacy of ...
Ekblad, Kristin, Bokenblom, Mattias
openaire   +2 more sources

Relocalising the food chain: the role of creative public procurement [PDF]

open access: yes, 2002
The conventional food chain presents a challenge to sustainable development, containing hidden costs such as health bills, environmental damage and economic costs to the rural economy.
Morely, Adrian, Morgan, Kevin
core  

"Now he walks and walks, as if he didn't have a home where he could eat": food, healing, and hunger in Quechua narratives of madness [PDF]

open access: yes, 2013
In the Quechua-speaking peasant communities of southern Peru, mental disorder is understood less as individualized pathology and more as a disturbance in family and social relationships. For many Andeans, food and feeding are ontologically fundamental to
A Topor   +40 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

UNH Faculty Abroad Series; Spring 2011 [PDF]

open access: yes, 2011
Ruth Varner UNH Earth Systems Research Center February 17, 2011 Listening for Climate Change North of the Artic Circle Julie Bryce UNH Department of Earth Sciences March 24, 2011 Snapshots of Carbonated Deep Earth: Geochemical Adventures in Italy ...
Center for International Education
core   +2 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

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