Results 41 to 50 of about 6,297,850 (302)

Refocusing the Agenda of Public Education: District Mission Statements and the Manners of Democracy as a Way of Life [PDF]

, 2022
Mission statements and public statements of values are widely recognized as important for educational improvement, even if often ignored. The mission statements and supporting documents of Utah\u27s 41 school districts were analyzed to locate prominent ...
Bullough, Robert V
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Análise do Processo de Paz no Enclave de Cabinda

Cadernos de Estudos Africanos, 2010
This paper aims to present a social political approach of the constraints and challenges arising from the peace process of Cabinda Agreement negotiated in Brazzaville, on July 13-15, 2006, and signed on August 1st of the same year between the Government ...
Miguel Domingos Bembe
doaj   +1 more source

Democratization of Serbian society through the prism of property tax [PDF]

Sociološki Pregled, 2022
The process of fiscal decentralization, typical of contemporary societies, in addition to the fiscal effect, also has a political effect. Namely, because bearers of political power need to get closer to citizens, fiscal decentralization is often seen ...
Cvjetković-Ivetić Cvjetana M., Milošević Goran B., Milašinović Srđan M.   +2 more
doaj  

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Consuming democracy : local agencies and liberal peace in the Democratic Republic of Congo [PDF]

, 2012
This thesis focuses on liberal peace building in the DRC. The thesis takes a critical approach which emphasises local agencies and their engagements with liberal peace building. However, it seeks to bring this critique back to the institutions with which
De Goede, Meike J.
core   +2 more sources

Local Democracy Revisited [PDF]

, 2013
The reform of institutional arrangements at the local level especially the personalisation of executive power and the implementation of new options to participate was expected to reinforce local democracy However there were doubts from the start as ...
Dr Hiltrud Nassmacher
core  

Researching Holistic Democracy in Schools. A Reponse to Examination of the New Tech Model as a holistic Democracy [PDF]

, 2017
Bradley-Levine reported in her article how she created an opportunity to explore research data with the aim of examining the degree to which New Tech schools were democratic in the sense conceptualized by the notion of holistic democracy.
Woods, Philip A
core   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source