Results 81 to 90 of about 4,591,312 (294)

On variability in local field potentials

Abstract Neuronal coding and decoding would be compromised if neuronal responses were highly variable. Intriguingly, neuronal spike counts (SCs) show a reduction in across-trial variance (ATV) in response to sensory stimulation, when SC variance is normalized by SC mean, that is, when using the Fano factor
Mohsen Parto-Dezfouli, Elizabeth L. Johnson, Eleni Psarou, Conrado Arturo Bosman, B. Suresh Krishna, Pascal Fries   +5 more
openaire   +3 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

The spin angular gradient approximation in the density functional theory

, 2002
A spin angular gradient approximation for the exchange correlation magnetic field in the density functional formalism is proposed. The usage of such corrections leads to a consistent spin dynamical approach beyond the local approximation.
A. I. Liechtenstein, C. Herring, C. S. Wang, D. M. Edwards, J. Callaway, J. P. Perdew, K. Capelle, M. Gell-Mann, M. I. Katsnelson, M. van Schilfgaarde, M. Ya. Amusya, O. Gunnarsson, P. A. Fedders, R. O. Jones, U. von Barth, V. P. Antropov, V. P. Antropov, V. P. Antropov, V. P. Antropov, V. P. Antropov   +19 more
core   +1 more source

The Local Field Potential Reflects Surplus Spike Synchrony [PDF]

Cerebral Cortex, 2011
45 pages, 8 figures, 3 supplemental ...
Denker, Michael, Roux, Sébastien, Lindén, Henrik, Diesmann, Markus, Riehle, Alexa, Grün, Sonja   +5 more
openaire   +4 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Asymptotic safety in three-dimensional SU(2) Group Field Theory: evidence in the local potential approximation

, 2017
We study the functional renormalization group of a three-dimensional tensorial Group Field Theory (GFT) with gauge group SU(2). This model generates (generalized) lattice gauge theory amplitudes, and is known to be perturbatively renormalizable up to ...
Carrozza, Sylvain, Lahoche, Vincent
core   +3 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Deep learning based decoding of single local field potential events

NeuroImage
How is information processed in the cerebral cortex? In most cases, recorded brain activity is averaged over many (stimulus) repetitions, which erases the fine-structure of the neural signal. However, the brain is obviously a single-trial processor. Thus,
Achim Schilling, Richard Gerum, Claudia Boehm, Jwan Rasheed, Claus Metzner, Andreas Maier, Caroline Reindl, Hajo Hamer, Patrick Krauss   +8 more
doaj   +1 more source

Coordination dynamics in cognitive neuroscience

Frontiers in Neuroscience, 2016
Many researchers and clinicians in cognitive neuroscience hold to a modular view of cognitive function in which the cerebral cortex operates by the activation of areas with circumscribed elementary cognitive functions.
Steven L Bressler, Scott Kelso, Scott Kelso   +2 more
doaj   +1 more source