Results 91 to 100 of about 2,273,193 (314)

Measuring efficiency in local governemnts’ planning and regulatory function

, 2000
Local government in advanced economies is undergoing a period of rapid reform aimed at enhancing its efficiency and effectiveness. However, despite the importance of efficiency measurement in local government it is only relatively recently that ...
Worthington, Andrew C., Dollery, Brian E.   +1 more
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FLORA: a novel method to predict protein function from structure in diverse superfamilies [PDF]

, 2009
Predicting protein function from structure remains an active area of interest, particularly for the structural genomics initiatives where a substantial number of structures are initially solved with little or no functional characterisation.
Dallman Timothy J., Nussinov, R., Oliver C. Redfern, Christine A. Orengo, Sillitoe, I., Dessailly Benoît H., Orengo, C.A., Benoît H Dessailly, Redfern, OC, Timothy J. Dallman, Oliver C Redfern, Benoît H. Dessailly, Dallman, TJ, Dessailly, B.H., Orengo Christine A., Ian Sillitoe, Timothy J Dallman, Sillitoe, I, Redfern Oliver C., Christine A Orengo, Dallman, T.J., Sillitoe Ian, Dessailly, BH, Redfern, O.C., Orengo, CA   +24 more
core   +1 more source

Locally uniformly continuous functions [PDF]

Proceedings of the American Mathematical Society, 1994
It is shown that on every infinite-dimensional separable normed space there exist continuous real-valued functions that are nowhere locally uniformly continuous. An explicit example of such a function on
openaire   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Algorithm 2. Local moving function.

, 2014
Algorithm 2. Local moving function.
John K. Heath (250134), Yunpeng Liu (379288), Xin Yao (130614), Zexuan Zhu (296894), Shan He (121220), Daniel A. Tennant (206938)   +5 more
core   +1 more source

ILC2 Orchestration of Local Immune Function in Adipose Tissue

Frontiers in Immunology, 2019
ILC2s were originally identified as IL-5 and IL-13 secreting “natural helper cells” present within the fat-associated lymphoid clusters of the mesenteries in both mouse and man. The presence of ILCs in adipose tissue has more recently expanded to include
Cécile Bénézech, Lucy Helen Jackson-Jones   +1 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Demand for Local Public Schooling: Another Brick in the Wall. [PDF]

In this paper we investigate the demand for local public school expenditures in Sweden. By using survey data, a method previously never applied to Swedish data, the paper provides an additional piece of evidence on individual demand for publicly provided
Ahlin, Åsa, Johansson, Eva
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