Results 131 to 140 of about 2,273,193 (314)

Local complexity of Boolean functions

Discrete Applied Mathematics, 2004
Summary: Classes of locally complex and locally simple functions are introduced. The classes are proved to be invariant with respect to polynomially equivalent complexity measures. A relationship is considered between proving that a function belongs to a class of locally complex functions and proving lower bounds for Boolean circuits, switching ...
openaire   +2 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Measuring Efficiency in Local Government: An Analysis of New South Wales Municipalities’ Domestic Waste Management Function

, 2001
Data envelopment analysis (DEA) is used to measure the technical and scale efficiency of the domestic waste management function in 103 New South Wales’ local governments. After allowance is made for nondiscretionary environmental factors which may affect
Worthington, Andrew C., Dollery, Brian E.   +1 more
core   +1 more source

Local structural modelling and local pair distribution function analysis for Zr–Pt metallic glass

Scientific Reports
In disordered glass structures, the structural modelling and analyses based on local experimental data are not yet established. Here we investigate the icosahedral short-range order (SRO) in a Zr–Pt metallic glass using local structural modelling, which ...
Akihiko Hirata, Satoru Tokuda, Chihiro Nakajima, Siyuan Zha   +3 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

From buildings to cities: techniques for the multi-scale analysis of urban form and function

, 2010
The built environment is a significant factor in many urban processes, yet direct measures of built form are seldom used in geographical studies. Representation and analysis of urban form and function could provide new insights and improve the evidence
Smith, D., Crooks, A.
core  

The Local Formulation for the Modified Green's Function Method

Latin American Journal of Solids and Structures
The Modified Global Green's Function Method (MGGFM) is an integral technique that is characterized by good accuracy in the evaluation of boundary fluxes.
Renato Barbieri, Roberto Dalledone Machado   +1 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Local Polynomial Variance Function Estimation

, 1995
Local Polynomial Variance Function ...
Holst, U., Ruppert, D., Hossjer, O., Wand, M.P.   +3 more
core  

UK public sector reform and the "performance agenda" in UK local government: HRM challenges and dilemmas

, 2005
Purpose – To examine how an external performance review process introduced as part of the public sector modernisation agenda in England and Wales has impacted on HR service provision and processes in local government and the extent to which it has acted ...
Harris, L
core   +1 more source