Results 61 to 70 of about 193,471 (315)
Pedestrians’ infrastructure design and everyday mobility navigation in urban Wa, Ghana
Despite the effort in safeguarding pedestrians through the provision of pedestrians’ infrastructure, studies have shown that motorists and pedestrians crash are yet occassioned by non-utilization of existing pedestrians’ infrastructure in cities of the ...
Nicholas Kombonaah +2 more
doaj +1 more source
Corruption, regionalization and local governance [PDF]
Corruption is old almost as human societies and it was developed simultaneously with enlargement of social and political power, bureaucracy and involvement of the state into market transactions.
Vuković Slobodan V.
doaj +1 more source
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Trauma is one of the leading causes of death in Western countries and results in severe health, economic, and social consequences due to residual disabilities.
Riccardo Mazzucco +8 more
doaj +1 more source
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Against the backdrop of intensified labor market competition, youth in underdeveloped regions face heightened structural constraints. It is crucial to understand the specific characteristics of their career expectations and job preparation, as well as ...
Xin Zhong, ZeKun Wang
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Climate change policy, conflict and transformative governance [PDF]
Climate change is the behemoth of our age. It defies description, is too large to comprehend, and what we do understand about it is often terrifying. This is for many, a good reason to stop thinking about it or, like Scarlett O’Hara, decide to “think ...
Melissa Nursey-Bray
core
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source

