Results 41 to 50 of about 1,689,021 (305)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

FINANCIAL DESTABILISATION OF POLISH LOCAL GOVERNMENT UNITS

open access: yesGlobalization, the State and the Individual, 2021
The aim of the study is to indicate the causes destabilising the financial situation of local government units in Poland. Their identification and subsequent verification will allow a diagnosis to be made as to whether it is possible to bring about a stabilisation of the financial situation of these units within a more defined period of time.
openaire   +1 more source

ANALYSIS OF LOCAL GOVERNMENT UNITS IN POLAND

open access: yesGlobalization, the State and the Individual, 2023
The subjectivity and independence of local self-government expressed in theConstitution of the Republic of Poland and concretized in local government laws has a systemicsignificance for determining its position in the state and in the law. Local self-government isthe key principle of the organization of public administration in Poland.
openaire   +1 more source

Research training in a ‘real-life’ survey [PDF]

open access: yes, 1993
A whole course or module is built round a survey research project devised in collaboration with a partner agency which may be an outside body (e.g. local government) or a unit in the teaching institution (such as a research group or the library). Other
Bonney, N., van Teijlingen, Edwin
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Local context of local government participation in the innovation networks: Evidence from Poland

open access: yesInternational Journal of Management and Economics, 2023
Innovation networks help to create innovation ecosystems by strengthen interactions between government, academia, business, and special institutions.
Godlewska Malgorzata, Mackiewicz Marta
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Interes prawny jednostki samorządu terytorialnego w perspektywie tzw. rozporządzenia terytorialnego Rady Ministrów

open access: yesActa Iuris Stetinensis, 2023
The article adresses the legal interest of a unit of local government in the perspective of the so-called territorial regulation. The subjective scope of the considerations covers the municipality, poviat and self-governing voivodeship, which obliges to ...
Joanna Bigos
doaj   +1 more source

Pengaruh Kompetensi Sumberdaya Manusia, Penerapan Sistem Pengendalian Intern, Penerapan Standard Akuntansi Pemerintah, Pemanfaatan Teknologi Informasi Dan Peran Inspektorat Terhadap Kualitas Laporan Keuangan Pemerintah Daerah (Studi Empiris Pada SKPD Dinas dan Badan Kabupaten Sukoharjo) [PDF]

open access: yes, 2018
The purpose of this research is to analyze the influence of Human Resource Competence, Internal Control System, Application of Government Accounting Stadar, Utilization of Technology and Role of Inspectorate on Quality of Local Government Financial ...
ris,, Drs. Mochamad Abdul A, M.Si   +1 more
core  

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