Results 81 to 90 of about 7,800,970 (362)

The Debt Consolidation of Hungarian Local Governments [PDF]

open access: yes, 2014
The total debt of Hungarian local governments accumulated during the 2002–2008 period was consolidated in full by the government between 2011 and 2014.
Lentner, Csaba
core  

Empowering Local Governments? The LOKAL+ project in Haiti

open access: yes, 2021
In Haiti, the traditional centralization of power in Port-au-Prince has far-reaching effects, one of which is the limited influence of ordinary citizens on holding local officials accountable for providing basic services like trash removal ...
Tonny, Joseph
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

Local governments at the UNFCCC COP17/CMP7: Urbanising the climate agenda - Highlights and key outcomes

open access: yes, 2011
Durban, South AfricaThe Durban Adaptation Charter complements the “Global Cities Covenant on Climate - the Mexico City Pact” and ‘carbon n’ Cities Climate Registry through which cities and other local governments measure, report and verify their GHG ...
ICLEI - Local Governments for Sustainability
core  

The Impact of Outsourcing and Full-Cost pricing initiatives on Local governments

open access: yes, 2023
Outsourcing has become a regular practice in the Australian public sector, including in local governments, which have increasingly used outsourcing mechanisms to reduce costs and deliver services (Blank & Niaounakis 2021).
Soar, Jeffrey, Manton, Carl, Lyons, Ben
core  

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

open access: yesMolecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini   +1 more
wiley   +1 more source

Myopic or constrained by balanced-budget-rules? The intertemporal spending behavior of Norwegian local governments [PDF]

open access: yes
The paper analyzes the intertemporal spending behavior of Norwegian local governments with particular attention to liquidity constraints imposed by balanced-budget-rules (BBRs). The main findings are: (i) On average, local government spending behavior is
Per Tovmo, Lars-Erik Borge
core  

Sustainability Management and Local Governments

open access: yes, 2018
After highlighting the breadth and complexity of the concept of sustainability and highlighting the role of local authorities in sustainable development, this chapter aims to interpret how sustainability management can consider the concept of financial ...
Fabio De Matteis, Daniela Preite
core   +1 more source

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