Results 81 to 90 of about 425,228 (311)

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Local Economics Empowerment and Sharia Microfinance in Rural Community Perception

Shirkah, 2017
This paper proposes to analyze and gain empirical evidences of the rural community perception on sharia micro finance institution to empower local economics at Margoyoso-Pati District Central Java, Indonesia. The data were gathered with survey method and
Umiyati
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Local Institution in Utilization of the Water Resources of The Giam Siak Kecil - Bukit Batu Biosphere Reserve, in Riau, Indonesia

Mimbar, 2016
The Giam Siak Kecil - Bukit Batu (GSKBB) Biosphere Reserve in Riau Province has flood swamp forest ecosystem, which are served as the primary fisheries resource for the local community. This research is aimed to determine the characteristics of resources
Nurul Qomar, Sambas Basuni, Rinekso Soekmadi, Herwasono Soedjito   +3 more
doaj  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

LOCAL OMBUDSMAN INSTITUTION IN SERBIA AND SPAIN WITH A SPECIAL OVERVIEW OF THE PROCEDURE FOR THE LOCAL OMBUDSMAN ELECTION

Pravo, 2013
Human freedoms and rights are one of the most significant creations of a man. Ombudsman institution occurs in the overall context of human freedoms and rights, with the aim of protecting and enabling people to realize their rights.
Aleksandar Grujić
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Fish bone ingestion presenting to a local institution in Singapore. [PDF]

Singapore Med J, 2020
Cheok S, Mak MHW, Rambachan SD, Chia CLK.   +3 more
europepmc   +1 more source

Le Pays entre institution et développement local

, 1999
Violier Philippe. Le Pays entre institution et développement local. In: Norois, n°181, 1999-1. « Pays » et développement local. Logique et ambiguïté d'une politique des territoires. pp.
Violier, Philippe
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source