Results 201 to 210 of about 164,160 (285)

Engineering the Host‐Graft Interface Stabilizes Vascular Integration and Improves Endocrine Function of Transplanted Ovarian Tissue

open access: yesAdvanced Science, EarlyView.
Conventional transplantation of human ovarian tissue results in early vascular infiltration that is not sustained over time. Engineering the host‐graft interface by combining multiple, smaller ovarian tissue pieces with a microporous annealed particle (MAP) hydrogel instead supports sustained tissue revascularization and perfusion.
Despina I. Pavlidis   +11 more
wiley   +1 more source

A Novel Bioactive Component, Efoba, From Aged Garlic Targets CTSC to Suppress NET‐Driven Neuroinflammation and Ameliorate Secondary Brain Injury After Intracerebral Hemorrhage

open access: yesAdvanced Science, EarlyView.
Efoba, a novel bioactive component derived from aged garlic, confers neuroprotection against intracerebral hemorrhage. It acts on microglia to suppress CTSC release, inhibits NET‐mediated neural injury, and blocks pathological microglia‐neutrophil crosstalk. This study provides a highly promising lead compound for hemorrhagic‐stroke therapy.
Junjun Meng   +7 more
wiley   +1 more source

CKMT1 Counteracts VDAC1 Oligomerization‐Induced Neuronal Pyroptosis Through Steric Hindrance in Ischemic Stroke

open access: yesAdvanced Science, EarlyView.
CKMT1 inhibits VDAC1 oligomerization via a dual‐region mechanism: its NTD interacts with the VDAC1 C‐terminal domain, while residues 1–39 sterically hinder dimerization, thereby reducing mtDNA leakage and AIM2 inflammasome activation, suppressing neuronal pyroptosis and protecting against cerebral ischemic injury. ABSTRACT Ischemic stroke is one of the
Xiaoyu Wang   +17 more
wiley   +1 more source

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