Results 81 to 90 of about 16,412 (257)

Pengaruh Kepemimpinan Servant terhadap Kinerja Karyawan Moderasi Kepribadian Karyawan di Kantor Gubernur Provinsi Riau

Jurnal Akutansi Manajemen Ekonomi Kewirausahaan
This study aims to analyze the influence of servant leadership on employee performance with employee personality as a moderating variable in the Riau Province Governor's Office.
Damri, Mhd Delvianto
doaj   +1 more source

GAYA KEPEMIMPINAN KEPALA DESA DALAM PELAYANAN PUBLIK: STUDI KASUS KABUPATEN INDRAGIRI HILIR RIAU

Humanus: Jurnal Ilmiah Ilmu-ilmu Humaniora, 2014
The study objective is to reveal the relation between the village head leadership style and financial factor and its effect to the quality of public service in Indragiri Hilir Regency, Riau Province.
Mukhammad Aras Bin Mannek, Samihah Khalil @ Halim   +1 more
doaj   +1 more source

Adaptive Leadership Styles and Organizational Performance: Evidence from Local NGOs in Ethiopia

Innovation Journal of Social Sciences and Economic Review
The objective of this study was to examine the influence of leadership styles on the performance of local NGOs in Ethiopia. A mixed-method design, combining descriptive survey and correlational approaches, was employed. Data were collected through structured questionnaires administered to 276 Chief Executive Officers (CEOs) and 199 board chairpersons ...
Lakachew Zeleke, Wario Guyo, Makori Moronge   +2 more
openaire   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

INTEGRATING ASTA BRATA VALUES IN INDONESIAN ELEMENTARY SCHOOL PRINCIPAL LEADERSHIP: A QUALITATIVE CASE STUDY

Research in Education and Rehabilitation
The academic inquiry has paid significant attention to leadership style, which profoundly impacts an organization’s development and progress. Scholars claim that this is of paramount importance for an organization to succeed.
Basilius Redan Werang, Anak Agung Gede Agung, I Nyoman Jampel, I Ketut Gading, I Made Suarjana, I Gede Margunayasa, Ni Luh Putu Risna Chayani   +6 more
doaj  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source