Results 181 to 190 of about 7,858,530 (320)

Clinical Model‐Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor, Takanobu Nadai, Kei Irie, Wen Rui Tan, Sanjana Parikh, Anhar Hosawi, Matthijs W. van Hoogdalem, Ronaldo Morales Junior, Sonya Tang Girdwood, Abbie D. Leino, Kana Mizuno, Alexander A. Vinks, Tomoyuki Mizuno   +12 more
wiley   +1 more source

Natural Selection as a Process That Increases Metabolic Entropy Production? A Regime-Dependent Analysis in Open Chemostat Systems with Michaelis-Menten Kinetics and Mutation-Selection Dynamics. [PDF]

Entropy (Basel)
Gioia L.
europepmc   +1 more source

Improved Conservative Scheme for Lenard‐Bernstein Collisions in Gyrokinetic Turbulence Simulations

Contributions to Plasma Physics, EarlyView.
ABSTRACT Turbulence in the edge and scrape‐off layer regions plays a critical role for the performance of future magnetic confinement fusion power plants. Gyrokinetic simulations allow studying this regime with high fidelity. A key aspect in these regions is the high concentration of impurities, which can radiate energy, leading to significant losses ...
Andrew Ivan Sulimro, Philipp Ulbl, Jordy Trilaksono, Frank Jenko   +3 more
wiley   +1 more source

Low-energy α -harmonic maps into the round sphere. [PDF]

Math Ann
Sharp B.
europepmc   +1 more source

ON LOCAL AND RATIO LIMIT THEOREMS

, 1967
openaire   +2 more sources

Upper bound limit analysis of coral reef limestone cavern roof stability incorporating a tension‐shear failure mechanism with tensile‐strength cut‐off

Deep Underground Science and Engineering, EarlyView.
For the roof of coral reef limestone caverns, a novel tension‐shear composite failure mechanism was developed. The most critical tensile crack model was identified using a hybrid optimization algorithm, and the stability of the cavern roof was analyzed accordingly.
Dongsheng Xu, Chenxu Li, Chuantan Hou
wiley   +1 more source

Central Limit Theorems For Multicolor Urns With Dominated Colors [PDF]

An urn contains balls of d >= 2 colors. At each time n >= 1, a ball is drawn and then replaced together with a random number of balls of the same color. Let An =diag (An,1, . . . ,An,d) be the n-th reinforce matrix. Assuming EAn,j = EAn,1 for all n and j,
Pietro Rigo, Luca Pratelli, Patrizia Berti, Irene Crimaldi   +3 more
core  

On Ergodic and Inverse Shadowing Properties of Set-Valued Mapping. [PDF]

F1000Res
Wattan Kamil F, Al-Shara'a IMT.
europepmc   +1 more source

Investigation on tunnel stability considering pipe‐roof support with transparent soil technology

Deep Underground Science and Engineering, EarlyView.
This study integrates transparent soil technology, 3D reconstruction and numerical simulation to captures the full‐field deformation of shield tunnel instability. Results demonstrate that pipe‐roof support enhances stability via the “soil‐arching barrier effect,” effectively restraining failure wedge development by extending stress transfer paths ...
Zhi Jia, Yunpeng Ji, Zhao Lu, Honghua Zhao, Limin Zhang   +4 more
wiley   +1 more source

Liquid-Vapor Transition in a Model of a Continuum Particle System with Finite-Range Modified Kac Pair Potential. [PDF]

Commun Math Phys
He Q, Jauslin I, Lebowitz J, Peled R.
europepmc   +1 more source