Results 51 to 60 of about 922,499 (265)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Exploring spatial narratives: A study of local memoirs from small towns in the Warsaw region

Res Rhetorica
This article investigates how spatial structuring in local memoirs from small towns in the Warsaw region functions as a rhetorical strategy of memory. By analysing how authors organise their narratives around places, use ekphrasis to engage materiality,
Agnieszka Szurek
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Report on the Results of Local Media for Better Society and Recommendations for Local Media [PDF]

, 2022
The project Local Media for Better Society, led by the Trade Union of Croatian Journalists, in partnership with BH Journalists Association, Independent Journalist’s Association of Serbia (IJAS), Slovene Association of Journalists (SAJ), and funded by the British Embassy in Zagreb, aims to provide cooperation and strengthening of independence of local ...
openaire  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Mediating Power-to-X: A case study of green imaginaries and environmental conflicts in local Danish news media

Nordicom Review
Recently, Power-to-X (PtX) has come to play a prominent role in the public discussion of a green energy future, with high hopes expressed by political and business players.
Horsbøl Anders
doaj   +1 more source

Emerging Forms of Hyperlocal Media

Nordicom Review, 2019
In the Nordic countries, local and regional newspapers have functioned as keystone media. This article examines the emergence of hyperlocal initiatives as part of evolving local media ecosystems in Finland, analysing the extent and characteristics of ...
Hujanen Jaana, Lehtisaari Katja, Lindén Carl-Gustav, Grönlund Mikko   +3 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Exploring the Visibility Gap Between Public Investment and Media Discourse in the Wrocław Participatory Budget

Applied Sciences
The purpose of this paper is to analyze the media visibility of investments implemented in Wrocław, with a particular focus on the democratization of urban processes through the Wrocław Participatory Budget (WPB) and to study the public perception of ...
Patryk Mierzejewski, Klaudiusz Tomczyk, Grzegorz Chrobak, Iwona Kaczmarek   +3 more
doaj   +1 more source