Results 61 to 70 of about 3,070,252 (279)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Urban Communication| Researching Local News in a Big City: A Multimethod Approach
International Journal of Communication, 2016 Reflecting on recent research in the United Kingdom, we consider how to investigate the mediation of news in a contemporary city. We put forward the notion of a “media ecology” to capture the relationships between varied news media and practices—from ...
Stephen Coleman +2 more
doaj +2 more sources
The Local TV News Experience: How to Win Viewers by Focusing on Engagement [PDF]
, 2007 Offers television stations insights to help them engage their audiences, stimulate strategic thinking about their position and role in the market, and connect with viewers in ways that could lead to improved civic ...
Bobby Calder +3 more
core
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Newspapers Turning Ideas into Dollars: Four Revenue Success Stories [PDF]
, 2013 The report follows a year-long effort to identify newspaper successes in the search for new business models. This report analyzes four such dailies -- the Naples (Fla.) Daily News, the Santa Rosa (Calif.) Press Democrat, the (Salt Lake City) Deseret News,
Amy Mitchell, Mark Jurkowitz
core
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Knowing their news: Library workers as informants to journalism studies research
Facts & FrictionsThis research note describes a new role for the public library: a knowledge base of community media information in the context of a larger journalism research project.
Tyler W.S. Nagel
doaj +1 more source
Logic of an Effectuating Hyperlocal
Nordicom Review, 2019 This article examines motivations, rewards and strategies in hyperlocal news entrepreneurship. The material is an interview study with eight entrepreneurs who independently own and manage hyperlocal news sites in Sweden.
Tenor Carina
doaj +1 more source
Molecular Oncology, EarlyView.Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser +14 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source