Results 51 to 60 of about 48,813 (257)

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

HLoOP—Hyperbolic 2-Space Local Outlier Probabilities

IEEE Access
Hyperbolic geometry has recently garnered considerable attention in machine learning due to its ability to embed hierarchical graph structures with low distortions for further downstream processing.
Clemence Allietta, Jean-Philippe Condomines, Jean-Yves Tourneret, Emmanuel Lochin   +3 more
doaj   +1 more source

Enhanced Connectivity Validity Measure Based on Outlier Detection for Multi-Objective Metaheuristic Data Clustering Algorithms

Applied Computational Intelligence and Soft Computing, 2022
Data clustering algorithms experience challenges in identifying data points that are either noise or outlier. Hence, this paper proposes an enhanced connectivity measure based on the outlier detection approach for multi-objective data clustering problems.
Hossam M. J. Mustafa, Masri Ayob
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Unsupervised Outlier Detection Mechanism for Tea Traceability Data

IEEE Access, 2022
The presence of outliers in tea traceability data can mislead customers and have a significant impact on the reputation and profits of tea companies. To solve this problem, an unsupervised outlier detection mechanism for tea traceability data is proposed.
Honggang Yang, Shaowen Li, Lijing Tu, Rongrong Ma, Yin Chen   +4 more
doaj   +1 more source

Spatial Outlier Detection of CO2 Monitoring Data Based on Spatial Local Outlier Factor

Journal of Engineering Science and Technology Review, 2015
Spatial local outlier factor (SLOF) algorithm was adopted in this study for spatial outlier detection because of the limitations of the traditional static threshold detection. Based on the spatial characteristics of CO 2 monitoring data obtained in the carbon capture and storage (CCS) project, the K-Nearest Neighbour (KNN) graph was constructed using ...
Liu Xin, Zhang Shaoliang, Zheng Pulin
openaire   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

Affinity Propagation Based on Structural Similarity Index and Local Outlier Factor for Hyperspectral Image Clustering

Remote Sensing, 2022
In hyperspectral remote sensing, the clustering technique is an important issue of concern. Affinity propagation is a widely used clustering algorithm.
Haimiao Ge, Liguo Wang, Haizhu Pan, Yuexia Zhu, Xiaoyu Zhao, Moqi Liu   +5 more
doaj   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source