Results 111 to 120 of about 128,875 (283)

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, EarlyView.
Doehl et al. discovered an adaptive neuroimmune mechanism that induces itch in tick‐exposed guinea pigs, enabling rapid tick removal. This itch‐induced tick removal (IITR) is mediated by an adaptive cellular immune response and is independent of IgG, IgE, or TRPV1.
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

Generating Dynamic Structures Through Physics‐Based Sampling of Predicted Inter‐Residue Geometries

Advanced Science, EarlyView.
While static structure prediction has been revolutionized, modeling protein dynamics remains elusive. trRosettaX2‐Dynamics is presented to address this challenge. This framework leverages a Transformer‐based network to predict inter‐residue geometric constraints, guiding conformation generation via physics‐based iterative sampling. The resulting method
Chenxiao Xiang, Wenkai Wang, Zhenling Peng, Jianyi Yang   +3 more
wiley   +1 more source

A Novel Approach Utilizing Bagging, Histogram Gradient Boosting, and Advanced Feature Selection for Predicting the Onset of Cardiovascular Diseases

Mathematics
Cardiovascular diseases (CVDs) rank among the leading global causes of mortality, underscoring the necessity for early detection and effective management.
Norma Latif Fitriyani, Muhammad Syafrudin, Nur Chamidah, Marisa Rifada, Hendri Susilo, Dursun Aydin, Syifa Latif Qolbiyani, Seung Won Lee   +7 more
doaj   +1 more source

Hierarchical Embedded Sphere Model: An Interpretable ML‐Guided Multiscale Descriptor Engineering Decodes OER Activity on TM@MO2 Catalysts

Advanced Science, EarlyView.
Hierarchical Embedded Sphere Model combines DFT and interpretable machine learning to decode catalytic activity on TM‐doped MO2. It disentangles global electronic, active‐site, and local coordination effects, revealing two activation mechanisms: dopant‐driven (Rh@MO2) and coordination‐mediated (Fe@ZrO2).
Ziyuan Li, Shan Gao, Yunhan Wang, Yueyu Zhang, Weichao Wang, Xiangmei Duan   +5 more
wiley   +1 more source

cuteHap: Haplotype‐Aware Structural Variant Detection in Phased Long‐Read Sequencing Data

Advanced Science, EarlyView.
cuteHap is a haplotype‐aware structural variant detection method designed for phased long‐read sequencing. By employing self‐adaptive clustering and credibility‐prioritized beam search algorithms, cuteHap generates accurate haplotype‐resolved calls and outperforms state‐of‐the‐art tools.
Shuqi Cao, Yadong Liu, Miao Cui, Runtian Gao, Weimin Guo, Guohua Wang, Yadong Wang, Tao Jiang   +7 more
wiley   +1 more source

SAGE: Spatially Aware Gene Selection and Dual‐View Embedding Fusion for Domain Identification in Spatial Transcriptomics

Advanced Science, EarlyView.
SAGE is a unified framework for spatial domain identification in spatial transcriptomics that jointly models tissue architecture and gene programs. Topic‐driven gene selection (NMF plus classifier‐based scoring) highlights spatially informative genes, while dual‐view graph embedding fuses local expression and non‐local functional relations.
Yi He, Yunpei Xu, Liqing Ding, Hong‐Dong Li, Yaohang Li, Shaokai Wang   +5 more
wiley   +1 more source

Identifying Tampered Radio-Frequency Transmissions in LoRa Networks Using Machine Learning

Sensors
Long-range networks, renowned for their long-range, low-power communication capabilities, form the backbone of many Internet of Things systems, enabling efficient and reliable data transmission.
Nurettin Selcuk Senol, Amar Rasheed, Mohamed Baza, Maazen Alsabaan   +3 more
doaj   +1 more source

Phase Diagrams and Piezoelectric Properties of Wurtzite Al1−x−yScxGdyN Heterostructural Alloys

Advanced Science, EarlyView.
This study demonstrates ferroelectricity and piezoelectric properties improvement of quaternary wurtzite Al1−x−yScxGdyN${\rm Al}_{1-x-y}{\rm Sc}_x{\rm Gd}_y{\rm N}$ films, guided by density functional theory calculations. Wurtzite Al1−x−yScxGdyN${\rm Al}_{1-x-y}{\rm Sc}_x{\rm Gd}_y{\rm N}$ films have a high optical bandgap, enhanced piezoelectric ...
Julia L. Martin, Cheng‐Wei Lee, Nate S.P. Bernstein, Thi Nguyen, Ande Bryan, Eli Cooper, John S. Mangum, Sage R. Bauers, Andriy Zakutayev, Keisuke Yazawa, Prashun Gorai, Rebecca W. Smaha   +11 more
wiley   +1 more source

Hybrid Unsupervised Machine Learning for Insurance Fraud Detection: PCA-XGBoost-LOF and Isolation Forest

Journal of Information Systems and Informatics
Insurance fraud poses a significant threat to the financial stability of insurance companies, resulting in substantial economic losses. To combat this issue, this study proposes a novel unsupervised machine learning hybrid algorithm, integrating ...
Natsai Chapwanya, Karikoga Norman Gorejena   +1 more
doaj   +1 more source

Integrated Ultrasound Device for Precision Bladder Volume Monitoring via Acoustic Focusing and Machine Learning

Advanced Science, EarlyView.
We present a conformable wearable ultrasound patch for noninvasive bladder volume monitoring. A flexible PZT array combined with a concave acoustic lens concentrates acoustic energy and improves depth selectivity through the anterior pelvic wall.
Long Long Cao, Feng Wen Wang, Jingwei Xue, Fulei Liu, Ming Liang Jin   +4 more
wiley   +1 more source