The GPX3‐VCAM1 Axis Gates Pro‐Fibrotic Tubule Cell Fate in Hyperuricemic Nephropathy
Hyperuricemia induces NLRP3 inflammasome signaling activation and downregulation of GPX3 in proximal tubular epithelial cells, leading to oxidative stress–driven VCAM1 upregulation, emergence of pro‐fibrotic proximal tubule cells, macrophage recruitment, and renal fibrosis.
Yunfei Qi +11 more
wiley +1 more source
A dynamic Ag+─S coordinated hydrogel with a sulfur–oxygen competitive coordination allosteric switch enables reversible tuning between soft–adhesive and stiff–robust states. Integrated with a lightweight 1DCNN classifier, the smart glove system achieves 99.70% laboratory and 93.35% real‐wear material recognition accuracy, offering a paradigm for self ...
Shixia Lan +4 more
wiley +1 more source
High‐throughput Differential Dynamic Microscopy measures frequency‐resolved mechanical fingerprints from 3 to 10 μL$\umu{\rm L}$ mucus samples using only a few minutes of operator attention per sample. This automated analysis enables scalable mucus phenotyping for translational research by distinguishing mechanical heterogeneity among donors, disease ...
Feng Ling +18 more
wiley +1 more source
Robust Random Walk Based on Natural Neighbors for Outlier Detection. [PDF]
Chen K, Zhu W, Li T, Wang H.
europepmc +1 more source
A directionally ice‐templated sulfur cathode integrated with atomically dispersed Fe–N4 catalytic sites is developed for high‐performance lithium–sulfur batteries. The structure–catalysis synergy accelerates Li+ transport and polysulfide conversion, leading to high sulfur utilization and stable long‐term cycling performance.
Lin Shen +8 more
wiley +1 more source
Outlier detection of skill decision differences of football penalty takers from a data-driven perspective: multialgorit hm modeling and empirical research of eye-tracking data. [PDF]
Li Z, Hu P, Liu H, Dai RC.
europepmc +1 more source
Predicting Enzyme Turnover Numbers and Enabling Rational Enzyme Evolution
MCKcat, a deep learning framework combining multi‐scale convolution and cross‐attention, accurately predicts enzyme turnover number (kcat) by fusing sequence and reaction representations. It couples with rational design in a two‐step strategy for Bacillus aryabhattai laccase engineering, achieving a 75% positive rate with synergistically enhanced ...
Fengya Ge +6 more
wiley +1 more source
Adaptive Kernel Density Soft-Gating for Robust GNSS/INS Georeferencing of Highly Dynamic Remote-Sensing Platforms Under Measurement Outliers. [PDF]
Feng K, Li J, Sun Z.
europepmc +1 more source
Brain Network Dynamics of Local and Global Predictive Processing in Aging
Separation of concurrent whole‐brain networks in source‐reconstructed magnetoencephalography (MEG) data suggests that healthy aging reorganizes, rather than uniformly attenuates, neural responses elicited from hierarchical auditory violations. Enhanced early sensory deviance processing alongside reduced higher‐order cognitive responses suggests a large‐
Mathias Houe Andersen +9 more
wiley +1 more source
An Online Detection and Rejection Method for Consecutive Outliers in Underwater Long-Baseline Positioning Based on Kinematic Constraints. [PDF]
Wang L, Su J, Mao R, Wang S.
europepmc +1 more source

