Results 31 to 40 of about 107,396 (309)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Amerikan Hukuk Sistemini Yerel Siyaset Üzerinden Okumak

open access: yesAnadolu Üniversitesi Hukuk Fakültesi Dergisi, 2021
1970 basımı ‘The Politics of Local Justice’ isimli, James R. Klonoski ve Robert I. Mendelson editörlüğünde hazırlanan kitap , eski tarihli olsa da günümüzde de geçerliliğini koruyan sorunları ele almaktadır.
İlknur Rabia Türkölmez
doaj  

Fiscal decentralization and development: How crucial is local politics? [PDF]

open access: yes, 2010
Does fiscal decentralization in a politically decentralized less developed country help strengthen democratic institutions at the grass root level? And is the impact of such decentralization on local politics important in determining local development ...
Pal, Sarmistha   +3 more
core  

Local government from Thatcher to Blair: The politics of creative autonomy

open access: yes, 2001
Published online: 09 Jun 2010See pg. 19-20 of pdf to view this book reviewBook Review: Hugh Atkinson and Stuart Wilks-Heeg, Local Government from Thatcher to Blair: The Politics of Creative Autonomy (Cambridge: Polity Press, 2000), 299 pp., US$22.95 ...
Robbins, John Richard
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

Geographies and politics of localism: the localism of the United Kingdom's Coalition Government

open access: yes, 2013
There has always been a localist element to British politics. But recently, a particular version of localism has been moved to the foreground by the 2011 Localism Act.
Cochrane, Allan, Clarke, Nick
core   +1 more source

Active Citizenship and the Governmentality of Local Lesbian and Gay Politics [PDF]

open access: yes, 2006
This paper explores the relationship between new forums of speakability and continuing unthinkability in the context of British local government lesbian and gay work, particularly post-1997.
Cooper, Davina
core   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

open access: yesFEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas   +6 more
wiley   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

open access: yesAging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss   +12 more
wiley   +1 more source

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