Results 81 to 90 of about 6,927,570 (328)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Local Protection: Raising a Matter of \u27Sovereign Concern\u27 [PDF]

open access: yes, 2001
Challenges to the expansion of local initiatives aimed at local environmental protection question the powers delegated to municipal governments from the state.
Nolon, John R.
core   +1 more source

La regulación del régimen local en la Comunidad Autónoma del País Vasco. Una cuestión pendiente

open access: yesRevista Vasca de Administración Pública, 2013
Both common institutions of the Autonomous Community of the Basque Country and the foral bodies of their historical territories have normative and executive powers in the field of local government.
José María Endemaño Arostegui
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

open access: yesMolecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy   +10 more
wiley   +1 more source

The role of local self-government in the Polish constitutional system [PDF]

open access: yesZbornik Radova Pravnog Fakulteta u Nišu, 2019
Local government reform has been acknowledged to be one of the biggest successes of political transformation in Poland. Municipalities (gminy) gained strong powers and are now responsible for many public services of crucial importance to local ...
Jakubek-Lalik Jowanka
doaj  

Homological Properties of Powers of the Maximal Ideal of a Local Ring

open access: yes, 2001
It is known that the powers m n of the maximal ideal of a local Noetherian ring share certain homological properties for all sufficiently large integers n .
L. Şega
semanticscholar   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

open access: yesFEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold   +11 more
wiley   +1 more source

Financial and legal mechanism for ensuring certain state powers delegated to local governments

open access: yesПравоприменение
The subject. The issues of applying the financial and legal mechanism for financing certain state powers transferred to local governments are considered.The purpose of the article is to identify the problems of legal regulation and practical im ...
I. V. Glazunova, V. B. Bashurov
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

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