Results 111 to 120 of about 992,631 (316)

FAIRS, FORMS OF EXPRESSION OF THE LOCAL IDENTITY CASE STUDY: BEIUȘ FAIR, BIHOR COUNTY, ROMANIA [PDF]

Analele Universităţii din Oradea: Seria Geografie, 2017
This study dwells on the role and the importance of fairs, and particularly about ”Beiuș Fair”, in conserving, promoting and capitalizing the identity of the local elements.
Grigore Vasile HERMAN, Larisa Bianca BENCHIȘ   +1 more
doaj  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Hochschild duality, localization, and smash products

Journal of Algebra, 2005
In this work we study the class of algebras satisfying a duality property with respect to Hochschild homology and cohomology, as in [Proc. Amer. Math. Soc. 126 (1998) 1345–1348]. More precisely, we consider the class of algebras A such that there exists an invertible bimodule U and an integer number d with the property H•(A,M)≅Hd−•(A,U⊗AM), for all A ...
openaire   +4 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

LOCALLY TABULAR PRODUCTS OF MODAL LOGICS

The Journal of Symbolic Logic
In the product $L_1\times L_2$ of two Kripke complete consistent logics, local tabularity of $L_1$ and $L_2$ is necessary for local tabularity of $L_1\times L_2$. However, it is not sufficient: the product of two locally tabular logics may not be locally tabular.
ILYA SHAPIROVSKY, VLADISLAV SLIUSAREV
openaire   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Global Product and Local Consequences. Case of Barbie

Contemporary Economics, 2009
Globalisation has turned various producers, such as international concerns, into leading actors on the global market. Their brands are recognised all around the world and their products are present in a significant number of households.
Piotr Pilch
doaj  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Analysis of Japanese and Finnish furniture design : a consideration for product identity and the relativity of industrial development and cultural context

, 2011
In a globalized product design market, firms take national identity into consideration to survive among the competitors, because a particular identifying feature can be the decision making factor for customers to buy a particular product.
Nakatani, Akiko
core  

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source