Results 91 to 100 of about 639,312 (344)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Inductive local-global conditions and generalised Harish-Chandra theory

Forum of Mathematics, Sigma
We study new properties of generalised Harish-Chandra theory aiming at explaining the inductive local-global conditions for finite groups of Lie type in nondefining characteristic.
Damiano Rossi
doaj   +1 more source

Learning Local Structured Correlation Filters for Visual Tracking via Spatial Joint Regularization

IEEE Access, 2019
Robust visual tracking is a fundamental problem in the field of computer vision and has a wide range of practical applications. Recent progress in developing robust tracking methods are mainly made upon discriminative correlation filters (DCF).
Chenggang Guo, Dongyi Chen, Zhiqi Huang
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Systemic and Local Administration of Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells Promotes Fracture Healing in Rats

Cell Transplantation, 2015
Mesenchymal stem cells (MSCs) are immune privileged and a cell source for tissue repair. Previous studies showed that there is systemic mobilization of osteoblastic precursors to the fracture site.
Shuo Huang, Liangliang Xu, Yifeng Zhang, Yuxin Sun, Gang Li M.B.B.S., D. Phil. (Oxon)   +4 more
doaj   +1 more source

Construction and Analysis of Functional Networks in the Gut Microbiome of Type 2 Diabetes Patients

Genomics, Proteomics & Bioinformatics, 2016
Although networks of microbial species have been widely used in the analysis of 16S rRNA sequencing data of a microbiome, the construction and analysis of a complete microbial gene network are in general problematic because of the large number of ...
Lianshuo Li, Zicheng Wang, Peng He, Shining Ma, Jie Du, Rui Jiang   +5 more
doaj   +1 more source

Connectivity properties of horospheres in Euclidean buildings and applications to finiteness properties of discrete groups [PDF]

, 2008
Let $\mathbf{G}(\mathcal{O}_{S})$ be an S-arithmetic subgroup of a connected, absolutely almost simple linear algebraic group G over a global function field K. We show that the sum of local ranks of G determines the homological finiteness properties of $\
Kai-Uwe Bux, Kevin A. Wortman
semanticscholar   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Altered functional network topology properties to detect anxiety and depression caused by Crohn’s disease and disease severity

Brain Research Bulletin
Objective: Here we investigated changes in topological properties of functional brain networks among individuals with Crohn’s disease (CD) and to determine whether these changes are related to CD severity, as well as CD-associated anxiety and depression,
Jiaxing Yang, Kechen Yue, Jingwen Sun, Changjie Pan, Xintong Wu, Yongjun Cheng, Xiaomeng Wu, Haifeng Shi   +7 more
doaj   +1 more source